PMID: 11933118Apr 5, 2002Paper

In vitro Inhibition of HHV-6 replication by sophocarpines

Phytotherapy Research : PTR
Hamida B QaviMushtaq A Khan

Abstract

The virostatic activity of sophocarpines and gancyclovir (GCV) was tested using HHV-6 Z29 strain and Molt-3 cells. The cytotoxic (IC(50)) and the antiviral (ED(50)) values were first experimentally determined and selective indices (SI) were then calculated. The SI values for sophocarpines 1 and 2 and GCV were in the order 184, 183, and 23, respectively. Though preliminary, these findings indicate that sophocarpines have the potential to inhibit HHV-6 replication.

References

Sep 13, 1991·Journal of Immunological Methods·N W RoehmA L Glasebrook
Feb 13, 1999·Multiple Sclerosis : Clinical and Laboratory Research·D V AblashiG R Pearson

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Citations

Nov 9, 2010·Journal of Gastroenterology and Hepatology·Chun-Yan SongYue-Xiang Chen
Feb 12, 2013·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Chun-Yan SongYue-Xiang Chen

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