In vitro inhibition of rabbit and Guinea pig erythrocyte acetylcholinesterase by soman

Toxicology in Vitro : an International Journal Published in Association with BIBRA
J Kassa, Jiri Bajgar

Abstract

Guinea pig and rabbit erythrocytes were incubated with a high concentration of soman to achieve zero acetylcholinesterase activity. After washing with saline, the erythrocytes were incubated with horse plasma butyrylcholinesterase. The inhibition of plasma butyrylcholinesterase activity was observed because of inhibitor release from the erythrocytes. This release was quantified and found to be the highest after 30min of incubation. Our results confirm that erythrocytes can serve as a depot for soman and make it possible to lengthen its toxic effects.

References

Jan 1, 1990·Archives of Toxicology·S ShapiraL Raveh
Oct 1, 1985·Archives of Toxicology·T KadarS Shapira
Sep 1, 1994·Journal of Applied Toxicology : JAT·R M Dawson
Jul 1, 1961·Biochemical Pharmacology·G L ELLMANR M FEATHER-STONE

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Citations

Jun 19, 2004·Inhalation Toxicology·Jiri BajgarHendrik P Benschop

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