In vitro inhibitory activity of citreoviridin against HIV-1 and an HIV-associated opportunist: Candida albicans

Journal of Chemotherapy
I VietaA Pugliese

Abstract

Citreoviridin, a mycotoxin produced by some molds of the genera Penicillium and Aspergillus, inhibits the growth of bacteria of the Bacillus genus. Since significant information was not available on the effects of citreoviridin on eukaryotic cells and viruses, this molecule was tested on CD4+ T-lymphoid cell lines, on HIV-1 and on Candida albicans, which sometimes complicates HIV-infection. Antiviral activity was detected in H9 HTLV IIIB cells, a clone chronically infected by HIV-1. Citreoviridin reduced p24 in the supernatant of H9 HTLV IIIB in a dose-dependent manner with a pharmacological selectivity index of 2.6. In C. albicans, the effects of the mold-derivative were evaluated on some parameters associated with pathogenicity and virulence: cellular proliferation, germ tube production, expression of heat shock mannoproteins, release of proteases and phospholipases. At a 12.5 microM dose, citreoviridin showed a marked inhibitory effect on all parameters analyzed. As regards the mechanism of action, it is possible to hypothesize that the effects of citreoviridin may be due to a reduction of protein synthesis, since it inhibited the replication of HIV-1 at post-integrational stages and reduced the intracellular RNA and protein...Continue Reading

References

Jan 1, 1992·Mycoses·A Polak
Jun 1, 1987·Journal of Virological Methods·R PauwelsM Vandeputte
Aug 30, 1984·Mycopathologia·P BoutibonnesC Marais
Feb 1, 1995·Journal of Chemotherapy·A PuglieseD Torre

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Citations

Nov 17, 2006·Expert Opinion on Investigational Drugs·Andrea Savarino
Jul 13, 2005·Natural Product Reports·Gerard P McGlacken, Ian J S Fairlamb
Jun 4, 2018·Applied Microbiology and Biotechnology·Wei LiWen-Bing Yin

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