In vitro injection of osteoporotic cadaveric femurs with a triphasic calcium-based implant confers immediate biomechanical integrity

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
John D StroncekM L Bouxsein

Abstract

Current pharmaceutical therapies can reduce hip fractures by up to 50%, but compliance to treatment is low and therapies take up to 18 months to reduce risk. Thus, alternative or complementary approaches to reduce the risk of hip fracture are needed. The AGN1 local osteo-enhancement procedure (LOEP) is one such alternative approach, as it is designed to locally replace bone lost due to osteoporosis and provide immediate biomechanical benefit. This in vitro study evaluated the initial biomechanical impact of this treatment on human cadaveric femurs. We obtained 45 pairs of cadaveric femurs from women aged 77.8 ± 8.8 years. One femur of each pair was treated, while the contralateral femur served as an untreated control. Treatment included debridement, irrigation/suction, and injection of a triphasic calcium-based implant (AGN1). Mechanical testing of the femora was performed in a sideways fall configuration 24 h after treatment. Of the 45 pairs, 4 had normal, 16 osteopenic, and 25 osteoporotic BMD T-scores. Altogether, treatment increased failure load on average by 20.5% (p < 0.0001). In the subset of osteoporotic femurs, treatment increased failure load by 26% and work to failure by 45% (p < 0.01 for both). Treatment did not sig...Continue Reading

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References

Nov 1, 1991·Journal of Biomechanical Engineering·S N RobinovitchT A McMahon
Jul 1, 1994·Calcified Tissue International·A C CourtneyW C Hayes
Jan 1, 1997·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B GullbergJ A Kanis
Oct 9, 2002·Journal of the American Geriatrics Society·Cynthia L LeibsonL Joseph Melton
Mar 26, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Felix EcksteinEva-Maria Lochmüller
Sep 28, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Socrates E PapapoulosDesmond E Thompson
Jun 9, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Monique ArlotErik Fink Eriksen
Sep 20, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·O Johnell, J A Kanis
Dec 6, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Russel BurgeAnna Tosteson
Aug 8, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Tony M KeavenyDennis M Black
Oct 9, 2008·The Journal of Clinical Endocrinology and Metabolism·E Michael LewieckiLorraine A Fitzpatrick
Jan 27, 2009·Clinical Biomechanics·T J van der SteenhovenR G H H Nelissen
Mar 5, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jesper RygPeter Vestergaard
Aug 13, 2009·The New England Journal of Medicine·Steven R CummingsUNKNOWN FREEDOM Trial
Jan 27, 2010·Journal of Orthopaedic Trauma·Scott C FaucettKenneth J Koval
Jan 27, 2010·Journal of Orthopaedic Trauma·Edward G SutterStephen M Belkoff
Feb 3, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E LandfeldtF Borgström
Mar 18, 2011·The Journal of Clinical Endocrinology and Metabolism·S BoonenM McClung
Apr 19, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J BeckmannM Gebauer
Apr 12, 2012·Journal of Biomaterials Applications·Ladina FliriMarkus Windolf
Sep 1, 2010·Geriatric Orthopaedic Surgery & Rehabilitation·Edward G SutterStephen M Belkoff
Jun 25, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Tony M KeavenyCesar Libanati
Aug 21, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·David L KopperdahlTony M Keaveny
Jan 3, 2014·The New England Journal of Medicine·Michael R McClungHenry G Bone
Jul 24, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S PapapoulosH G Bone
Jan 11, 2016·Archives of Orthopaedic and Trauma Surgery·Christoph RaasWerner Schmoelz
Aug 18, 2016·JAMA : the Journal of the American Medical Association·Paul D MillerUNKNOWN ACTIVE Study Investigators
Dec 27, 2016·BoneKEy Reports·Peter VargaMarkus Windolf
Jan 7, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A ModiS T Harris
May 26, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Tony M KeavenyCesar Libanati
Jul 26, 2017·Bone·Fjola JohannesdottirMary L Bouxsein
Oct 17, 2018·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisUNKNOWN Scientific Advisory Board of the European Society for Clinical and Economic Aspects of Osteoporosis (ESCEO) and the Committe

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Citations

Dec 6, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J G HoweB Huber
Feb 29, 2020·Archives of Orthopaedic and Trauma Surgery·Matthias TrostTobias Ludger Schulte
Dec 23, 2021·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jonathan ShaulJames Howe

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