In vitro interaction between ofloxacin and cefotaxime against gram-positive and gram-negative bacteria involved in serious infections

Chemotherapy
C GimenoJ García-de-Lomas

Abstract

The checkerboard method was used to determine the antimicrobial activity of the combination cefotaxime/ofloxacin against 217 bacterial isolates involved in serious infections. Synergy or partial synergy was observed against 19 of 34 (55.8%) Staphylococcus aureus methicillin-susceptible isolates, 4 of 47 (8.4%) Streptococcus pneumoniae isolates, 28 of 34 (82.2%) Escherichia coli isolates and 70 of 102 (68.5%) Pseudomonas aeruginosa isolates. Antagonism was not observed with any of the isolates examined.

Citations

Aug 22, 2000·Antimicrobial Agents and Chemotherapy·P M FurneriG Tempera
Jul 6, 2012·Clinical Microbiology Reviews·Pranita D TammaLisa L Maragakis
Mar 17, 2011·BMC Infectious Diseases·David OliveOlivier Leroy
Jul 20, 2010·Critical Care Medicine·Anand KumarUNKNOWN Cooperative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group
Aug 4, 2004·The Lancet Infectious Diseases·Nasia SafdarDennis G Maki
Jun 3, 2015·Current Infectious Disease Reports·Stephen Y Liang, Anand Kumar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.