In vitro interaction of antifungal and antibacterial drugs against Cryptococcus neoformans var. grubii before and after capsular induction

Medical Mycology
Luana RossatoSydney Hartz Alves

Abstract

This study evaluated the synergistic interactions between amphotericin B (AMB) and azithromycin (AZM), daptomycin (DAP), linezolid (LNZ), minocycline (MINO), fluconazole (FLZ), flucytosine (5FC), linezolid (LZD), or tigecycline (TIG) against clinical isolates of Cryptococcus neoformans var. grubii before and after capsule induction. High synergism (>75%) was observed for the combinations, AMB+5FC, AMB+TIG, AMB+AZM, AMB+LZD and AMB+MINO but only in the strains after capsule induction. The results show that the presence of the capsule may lower the minimum inhibitory concentrations (MICs) of antifungal agents, but antimicrobial activity can be improved by combining antifungal and antibacterial agents.

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Citations

Nov 5, 2016·International Journal of Antimicrobial Agents·Fernanda Sangalli-LeiteMaria José Soares Mendes-Giannini
Nov 10, 2018·International Journal of Medicinal Chemistry·Grady L NelsonSravan K Jonnalagadda
Jun 22, 2021·Applied Microbiology and Biotechnology·Qian ZhangZhangyong Song

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