In vitro interaction of fluconazole and trimethoprim-sulfamethoxazole against Candida auris using ETEST and checkerboard methods.

Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research
Heather R DavisGeorge A Pankey

Abstract

Candida auris was discovered in 2009 and has rapidly emerged as a serious public health threat with cases reported in over 20 countries worldwide. As of May 8, 2020, the Centers for Disease Control and Prevention reported a total of 1122 US cases. C. auris is often multidrug resistant, leaving few options for treatment. Sulfonamides are known to inhibit a bacterial enzyme involved in folate synthesis and may also inhibit yeast organisms by a similar mechanism. The combination of trimethoprim and sulfamethoxazole is more commonly used than either drug alone. The objective of this study was to evaluate the combination of fluconazole and trimethoprim-sulfamethoxazole against C. auris Minimum inhibitory concentrations (MICs) of fluconazole and trimethoprim-sulfamethoxazole were determined by ETEST and broth microdilution for 11 C auris strains. Fluconazole MICs (µg/mL) were 4->256 by ETEST and 2->256 by broth microdilution (73% resistant); trimethoprim-sulfamethoxazole MICs were >32 by ETEST and 32->128 by broth microdilution (no interpretive guidelines for C. auris). Using our MIC: MIC ETEST method and a checkerboard method, we investigated the interaction of fluconazole and trimethoprim-sulfamethoxazole against all isolates. Thes...Continue Reading

References

Jul 1, 2011·Journal of Clinical Microbiology·Wee Gyo LeeHee-Chang Jang
Jul 23, 2014·Antimicrobial Agents and Chemotherapy·George PankeyAbdulrahim Ismail
Dec 19, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Peter G PappasJack D Sobel
Dec 19, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Shawn R LockhartAnastasia P Litvintseva
Aug 30, 2017·Antimicrobial Agents and Chemotherapy·Hamed FakhimHamid Badali
Aug 27, 2018·International Journal of Antimicrobial Agents·Hassan E EldesoukyMohamed N Seleem
Sep 19, 2018·Emerging Infectious Diseases·Eleanor AdamsUNKNOWN Candida auris Investigation Workgroup
Jul 17, 2019·Emerging Infectious Diseases·Nancy A ChowJacques F Meis
Jan 15, 2020·Antimicrobial Agents and Chemotherapy·Brittany O'BrienVishnu Chaturvedi
Jan 20, 2020·International Journal of Antimicrobial Agents·A L BidaudE Dannaoui

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Citations

Jun 29, 2021·Expert Review of Clinical Pharmacology·Daniele R GiacobbeMatteo Bassetti

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