In vitro investigation of lipid implants as a controlled release system for interleukin-18

International Journal of Pharmaceutics
S KoenningsA Goepferich

Abstract

Operating on the inductive and effective phases of an anti-tumor immune response and uncovering pivotal functions that may reduce cancer cell growth, interleukin-18 (IL-18) appears to be an attractive candidate for the sustained local adjuvant immunotherapeutic treatment of brain gliomas. The objective of this work was to develop IL-18 loaded lipid implants as a controlled delivery system. For the preparation of protein loaded triglyceride matrix material, a solid-in-oil (s/o) dispersion technique was chosen for which protein particles in the micrometer range were first prepared by co-lyophilization with polyethylene glycol (PEG). Implants of 1 mm diameter, 1.8 mm height and 1.8 mg weight were manufactured by compression of the powder mixture in a specially designed powder compacting tool. The in vitro release behavior of 125I-Bolton-Hunter-radiolabeled IL-18 was assessed in a continuous-flow system. A cell culture assay was established for the determination of bioactivity of released IL-18. Implants showed a continuous release of 10-100 ng IL-18 per day for 12 days. A progressive integrity loss was observed with ongoing release, which would be related to protein degradation during incubation. The initially released fraction pr...Continue Reading

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Citations

Feb 2, 2008·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Manju RawatSwarnlata Saraf
Mar 6, 2008·Expert Opinion on Drug Delivery·Frauke KreyeJuergen Siepmann
Sep 12, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Gerhard Sax, Gerhard Winter
Sep 12, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Gerhard SaxGerhard Winter
Aug 2, 2011·International Journal of Pharmaceutics·J Siepmann, F Siepmann
Apr 6, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·F KreyeJ Siepmann
Mar 1, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·F KreyeJ Siepmann
Jul 28, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·A ZakyA Goepferich
Jan 6, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sandra Schulze, Gerhard Winter
Dec 19, 2008·Nanomedicine : Nanotechnology, Biology, and Medicine·Tessy LopezXim Bokhimi
Apr 30, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·F SiepmannJ Siepmann
Apr 13, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·S KoenningsA Goepferich
Apr 7, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·S KoenningsA Goepferich
Jun 13, 2012·The Journal of Pharmacy and Pharmacology·Jie Shen, Diane J Burgess
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May 30, 2014·Jundishapur Journal of Natural Pharmaceutical Products·Lana TamaddonFahimeh Asadi Amoli
Aug 29, 2021·Pharmaceutics·Ana JúlioTânia Santos de Almeida

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