In vitro investigation of lymph node metastasis of colorectal cancer using ultrasonic spectral parameters

Ultrasound in Medicine & Biology
T NoritomiKazuo Shirouzu

Abstract

Lymph node involvement is one of the major factors affecting the prognosis of colorectal cancer. Various imaging methods, including ultrasound and computed tomography, are not sufficiently sensitive or specific for reliably determining lymph node involvement. We investigated the feasibility of using ultrasonic tissue characterization (UTC) based on spectrum analysis of backscattered echo signals for diagnosing lymph node metastasis of colorectal cancer in vitro. Forty lymph nodes, including 17 metastatic and 23 nonmetastatic nodes, from 11 colorectal cancer operations were investigated. Lymph nodes were scanned using a clinical instrument; B-mode imaging was performed for each lymph node, and radiofrequency (RF) data were acquired. The UTC parameters, slope and intercept, were calculated from the normalized power spectrum of the backscattered echo signals from each lymph node. The mean values of UTC parameters of metastatic and nonmetastatic lymph nodes were compared. The accuracy of UTC in distinguishing metastatic from nonmetastatic lymph nodes was calculated using discriminant analysis. Receiver operating characteristic (ROC) analysis was performed to compare the classification efficacy of UTC and B-mode ultrasound. UTC para...Continue Reading

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Citations

Jun 25, 2002·Ultrasound in Medicine & Biology·M C KoliosM D Sherar
Aug 9, 2001·Current Opinion in Urology·M Ismail, L G Gomella
Sep 26, 2017·Ultrasonic Imaging·Pauline Muleki-SeyaWilliam D O'Brien

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