PMID: 6538913Mar 1, 1984Paper

In vitro leukocyte endogenous mediator production is not impaired following surgical stress in moderately malnourished patients

JPEN. Journal of Parenteral and Enteral Nutrition
J L DuncanG L Blackburn

Abstract

Leukocyte endogenous mediator (LEM), a protein produced by phagocytizing cells, plays a critical role in the metabolic response to injury and infection. There is an important interaction between protein-calorie malnutrition and the capacity of cells to produce LEM, since severely malnourished or severely stressed individuals, have a reduced capacity to produce LEM. The leukocytes of 10 mildly to moderately malnourished patients undergoing elective major surgery, a moderate stress, had an intact ability to produce LEM on preoperative assessment. This ability was not affected by a 5-day postoperative period of hypocaloric nutrient intake despite a significant loss of body protein in one-half of the patients and a significant fall in serum protein concentrations. These results suggest a high biologic priority for LEM production during the metabolic response to injury and for infection.

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Citations

Apr 1, 1992·Acta Anaesthesiologica Scandinavica·M Salo
Feb 1, 1989·The British Journal of Surgery·A M CruickshankA Shenkin
Mar 1, 1997·The Proceedings of the Nutrition Society·S D HeysO Eremin
Apr 29, 1999·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·A J MangramW R Jarvis
May 20, 2017·The Cochrane Database of Systematic Reviews·Joshua FeinbergJanus C Jakobsen

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