PMID: 11310498Apr 20, 2001Paper

In vitro loading of human synovial membrane with 5-hydroxydopamine: evidence for dense core secretory granules in type B cells

Archives of Histology and Cytology
F VandenabeeleJ Creemers

Abstract

Ultrastructural studies of the synovial membrane were performed on tissue samples obtained from the human lumbar facet joint. Ultrastructural changes in synoviocytes were studied after loading synovial samples with 5-hydroxydopamine (5-OHDA) in an oxygenated Krebs' solution, prior to fixation. Synoviocytes were set loosely in the intimal matrix and classified into type A (phagocytic) and type B (secretory) cells. In general, type A cells populated the surface of the synovial lining, whereas type B cells were located deeper in the tissue, extending a process into the synovial fluid. Type B cells in control samples contained sparse secretory granules. Free nerve endings were not found in the synovial intima. In response to incubation in 5-OHDA, a precursor of biogenic monoamines, synoviocytes clustered and established contact. The ultrastructure of type B cells in the loaded group clearly differed from controls. They possessed typical membrane-bound vesicles, containing an electron dense interior surrounded by a lucent space. The size of these dense core vesicles ranged from 100 to 260 nm (on average 180 nm). They were in relation to microtubules and located preferentially in the marginal area of the cytoplasm, close to the Golgi...Continue Reading

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Citations

Aug 10, 2011·Journal of Biomechanical Engineering·Nicolas V JaumardBeth A Winkelstein
Feb 16, 2008·PPAR Research·Daniel C Berry, Noa Noy
Jan 15, 2013·Journal of Tropical Medicine·Vitor R R de MendonçaManoel Barral-Netto
Jan 1, 2014·International Scholarly Research Notices·Ligabaw WorkuMulugeta Aemero

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