In vitro lymphocyte reactivity to rubella antigen following vaccination

Scandinavian Journal of Infectious Diseases
Z HeiglM Forsgren


In vitro lymphocyte stimulation and several serological tests were used to study the development of immunity after subcutaneous immunization with attenuated rubella virus. Maximal lymphocyte reactivity was obtained 3--4 months after vaccination and a decline after 1.5--2.5 years. Lymphocyte reactivity following natural immunity was of a higher magnitude. No correlation between the degree of lymphocyte stimulation and titers of neutralizing, hemagglutination inhibiting and hemolysis-in-gel antibodies was observed. The influence on the results of some methodological factors and different rubella antigens is discussed.


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Related Concepts

Antibodies, Viral
Antigens, Viral
Cell Separation
Antibody Dissociation
Differential White Blood Cell Count Procedure
Lymphocyte Activation
Lymphoid Cells
Rubella virus vaccine
Rubella virus

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