In vitro lymphocyte stimulation with specific antigen in congenital toxoplasmosis

Scandinavian Journal of Infectious Diseases
O Closs, B Stray-Pedersen

Abstract

The development of specific cell mediated immunity was studied in children with congenital toxoplasmosis and the in vitro lymphocyte stimulation test (LST) evaluated as diagnostic test for congenital infection. The test was performed in 35 children, including 5 with a confirmed or suspected congenital toxoplasmosis and for comparison, in 19 dye test positive and 7 negative women. The development of delayed type hypersensitivity (DTH) seemed to follow approximately the same time course in children with congenital toxoplasmosis as in adults with toxoplasmosis. The lymphocyte responses to toxoplasma antigen were low during the first year, but increased markedly during the second and third years after infection. Chemotherapy during the first year of life did not prevent the later development of DTH. It is concluded that a positive LST during the first year of life may be an indication of congenital toxoplasmosis. A negative test is not decisive.

References

Jan 1, 1979·Scandinavian Journal of Infectious Diseases·B Stray-Pedersen, A M Lorentzen-Styr
Mar 1, 1972·The Journal of Infectious Diseases·J L KrahenbuhlJ S Remington
Jan 1, 1970·The American Journal of Tropical Medicine and Hygiene·L Tremonti, B C Walton
Jan 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·F G Araujo, J S Remington
Feb 1, 1980·American Journal of Obstetrics and Gynecology·B Stray-Pedersen
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Jul 30, 1960·JAMA : the Journal of the American Medical Association·J K FRENKELM N LUNDE
Jul 1, 1948·Proceedings of the Society for Experimental Biology and Medicine·J K FRENKEL

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Citations

Jun 1, 1989·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·B LecolierG Sarrot
Jan 1, 1985·Journal of Clinical Microbiology·A MerliG Melioli

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