In vitro maturation for patients with polycystic ovary syndrome

Seminars in Reproductive Medicine
Shauna L Reinblatt, W M Buckett

Abstract

In vitro fertilization (IVF) with ovarian stimulation is an effective treatment for couples needing treatment with assisted reproductive technologies (ART) where polycystic ovary syndrome (PCOS) is coexisting. However, it is also associated with an increased risk of ovarian hyperstimulation syndrome. In vitro maturation (IVM) avoids the risks and side effects of ovarian stimulation by retrieving immature oocytes from unstimulated ovaries. These immature oocytes are then cultured, matured, and fertilized in vitro. Embryos are then selected for transfer in the same manner as conventional IVF. Although there has been significant progress in terms of improving clinical pregnancy and live-birth rates after IVM, there remains much to learn in terms of what controls maturation, fertilization, and implantation rates. This review is intended as an update on the most recent advances and directions of ongoing research in IVM in patients with PCOS.

Citations

Aug 26, 2010·Nature Reviews. Clinical Oncology·Joseph M LetourneauMitchell P Rosen
Oct 28, 2008·Seminars in Reproductive Medicine·Tannaz ToloubeydokhtiNasser Chegini
Aug 28, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Margarida Avo SantosNick S Macklon
Jan 19, 2012·Obstetrics and Gynecology International·I DemeestereE Shalom-Paz
Jul 24, 2012·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Einat Shalom-PazBenny Almog
Sep 9, 2010·Reproductive Biomedicine Online·Einat Shalom-PazSeang Lin Tan
Jul 2, 2011·Fertility and Sterility·Einat Shalom-PazHolzer Hananel
Jun 28, 2011·Fertility and Sterility·Einat Shalom-PazHananel Holzer
Nov 28, 2018·The Cochrane Database of Systematic Reviews·Charalampos S SiristatidisSiladitya Bhattacharya
May 25, 2021·The Journal of Obstetrics and Gynaecology Research·Ebru HatirnazMichael H Dahan

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