In vitro maturation (IVM) of oocytes in patients with resistant ovary syndrome and in patients with repeated deficient oocyte maturation

Journal of Assisted Reproduction and Genetics
A GalvãoM De Vos

Abstract

To assess the efficiency of IVM in patients with repeated ART failure due to resistant ovary syndrome or due to deficient oocyte maturation. Clinical and laboratory data were obtained retrospectively from 28 patients who underwent 49 cycles of IVM between 2010 and 2017; nine patients had resistant ovary syndrome and 19 patients had repeated deficient oocyte maturation. Nine patients with resistant ovary syndrome underwent 24 IVM cycles. In those, an average of 11.5 ± 10.4 cumulus-oocyte complexes (COC) was retrieved, and IVM resulted in 3.4 ± 3.1 mature oocytes. After ICSI and transfer of 23 cleavage-stage embryos, eight pregnancies were obtained, resulting in five healthy live births. The live birth rate was 16.7% per started cycle and 33.3% per patient. Nineteen patients with a history of deficient oocyte maturation underwent 25 IVM cycles. An average of 10.6 ± 9.2 COC was retrieved, and after IVM, 1.3 ± 2.1 oocytes were mature. No mature oocytes were obtained in 11 cycles. In ten cycles with mature oocytes, none of them fertilized after ICSI. Out of four cycles with fertilized oocytes, only one good-quality embryo was obtained. No live births were obtained after IVM in patients with a history of deficient oocyte maturation. ...Continue Reading

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Citations

Jun 17, 2020·Journal of Cellular Physiology·Samira AsghariAmir Valizadeh
Nov 21, 2020·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Safak HatirnazMichael H Dahan
Dec 29, 2020·Fertility and Sterility·UNKNOWN Practice Committees of the American Society for Reproductive Medicine, the Society of Reproductive Biologists and Technologi
Jan 27, 2021·Journal of Assisted Reproduction and Genetics·Nikolay Valerievich KornilovPavel Pavlovich Yakovlev
May 20, 2021·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Lucie Chansel-DebordeauxAline Papaxanthos-Roche
Jun 3, 2021·Reproductive Sciences·Xueqi GongYiqing Zhao
Jun 6, 2021·Journal of Assisted Reproduction and Genetics·Achraf BenammarMarine Poulain
Jul 5, 2021·Journal of Assisted Reproduction and Genetics·Michel De VosRobert B Gilchrist
Aug 28, 2021·Animals : an Open Access Journal From MDPI·Achraf BenammarPascale Chavatte-Palmer
Dec 1, 2021·Journal of Assisted Reproduction and Genetics·Ho Long LeLan Ngoc Vuong

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