PMID: 6650176Oct 1, 1983

In vitro metabolism of propoxyphene in rat liver: reaction of a carbinol metabolite with acetaldehyde

Acta Pharmacologica Et Toxicologica
I HermanssonN E Stjernström


The metabolism of the analgesic drug propoxyphene (alpha-d-propoxyphene) has been investigated in the rat liver 9,000 X g supernatant fraction. The incubations were analyzed by HPLC. The major metabolite was norpropoxyphene carbinol, obtained through demethylation and ester hydrolysis. The demethylated metabolite of propoxyphene, norpropoxyphene, was also detected. Addition of acetaldehyde to the incubation mixture decreased the metabolism of propoxyphene. Reactions between norpropoxyphene carbinol and acetaldehyde resulted in a fast disappearance of the carbinol and the formation of a reaction product, the significance of which is discussed.


Jan 1, 1978·Archives of Toxicology. Supplement. = Archiv Für Toxikologie. Supplement·J SchouJ M Christensen
Mar 1, 1978·Acta Pharmacologica Et Toxicologica·H Lund-Jacobsen
Jul 16, 1977·British Medical Journal·R M Whittington
Jan 1, 1977·Clinical Toxicology·T A RejentJ M Lehotay
Aug 1, 1977·Journal of Medicinal Chemistry·W W TurnerA Pohland
Oct 1, 1976·Biomedical Mass Spectrometry·S L DueR E McMahon
Jan 1, 1976·Annals of the New York Academy of Sciences·A W TankJ A Thurman
Jan 1, 1976·Annals of the New York Academy of Sciences·K BlumW W Morgan
Jan 1, 1976·Annals of the New York Academy of Sciences·S E GitlowB L Wong
Apr 30, 1973·Annals of the New York Academy of Sciences·M J Walsh
Jul 1, 1971·Toxicology and Applied Pharmacology·R E McMahonF J Marshall
Apr 12, 1980·British Medical Journal·R J Young, A A Lawson

Related Concepts

Norpropoxyphene carbinol hydrochloride
Metabolic Biotransformation
High Pressure Liquid Chromatography Procedure
Drug Interactions
Microsomes, Liver
Propoxyphene Sulfate, (S-(R*, S*))-Isomer
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