PMID: 2490562Jan 1, 1989Paper

In vitro metabolism studies on oxamniquine and related compounds by chiral liquid chromatography

Journal of Pharmaceutical and Biomedical Analysis
A F FellB Kaye

Abstract

A previously developed method based on alpha 1-acid glycoprotein for the resolution of the enantiomers of the Pfizer antischistosomal drug oxamniquine was used to examine possible enantioselectivity in the in vitro microsomal hydroxylation of a metabolic precursor, UK-3883, but was found to be limited by the poor operational stability of the analytical column ("EnantioPac") employed. As an alternative approach, a "Pirkle" covalently-bonded dinitrobenzoyl leucine column was used, with simple precolumn solute derivatization to the carbamate to improve chromatographic performance. The method allowed preliminary examination of the stereochemistry of the in vitro biotransformation, hydroxylation of UK-3883 to oxaminquine, which yielded evidence for substrate enantioselectivity in favour of the dextrorotatory enantiomer of UK-3883.

References

Mar 1, 1972·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·B Kaye, N M Woolhouse

❮ Previous
Next ❯

Citations

May 13, 1999·Il Farmaco·M RizkN M el-Enany
Aug 10, 2000·Journal of Pharmaceutical and Biomedical Analysis·M RizkN M El-Enany
Oct 21, 2015·PLoS Neglected Tropical Diseases·Alexander B TaylorPhilip T LoVerde
Jul 3, 2013·Angewandte Chemie·Sophie A-L Thétiot-LaurentBernard Meunier

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.