In vitro metabolism study of a black market product containing SARM LGD-4033

Drug Testing and Analysis
Lore GeldofK Deventer

Abstract

Anabolic agents are often used by athletes to enhance their performance. However, use of steroids leads to considerable side effects. Non-steroidal selective androgen receptor modulators (SARMs) are a novel class of substances that have not been approved so far but seem to have a more favourable anabolic/androgenic ratio than steroids and produce fewer side effects. Therefore the use of SARMs has been prohibited since 2008 by the World Anti-Doping Agency (WADA). Several of these SARMs have been detected on the black market. Metabolism studies are essential to identify the best urinary markers to ensure effective control of emerging substances by doping control laboratories. As black market products often contain non-pharmaceutical-grade substances, alternatives for human excretion studies are needed to elucidate the metabolism. A black market product labelled to contain the SARM LGD-4033 was purchased over the Internet. Purity verification of the black market product led to the detection of LGD-4033, without other contaminants. Human liver microsomes and S9 liver fractions were used to perform phase I and phase II (glucuronidation) metabolism studies. The samples of the in vitro metabolism studies were analyzed by gas chromatog...Continue Reading

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Citations

May 12, 2016·Drug Testing and Analysis·Holly D Cox, Daniel Eichner
Oct 21, 2018·Drug Testing and Analysis·Vinicius Figueiredo SardelaHenrique Marcelo Gualberto Pereira
Sep 27, 2018·Drug Testing and Analysis·Argyro G FragkakiYiannis Angelis
May 14, 2020·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Emiliano VenturaMark H Mooney
Dec 21, 2018·Medicinal Research Reviews·Dan LiTingjun Hou
Nov 18, 2017·Drug Testing and Analysis·Mario ThevisHans Geyer
Feb 6, 2017·Substance Use & Misuse·Christina WeberMario Thevis
Sep 23, 2020·Drug Testing and Analysis·Katja WalpurgisMario Thevis
Jul 6, 2021·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Amanda Lessa Dutra de AraujoCarina de Souza Anselmo
Aug 15, 2021·Journal of Pharmaceutical and Biomedical Analysis·Mario ThevisAndreas Thomas

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