In vitro microbial inhibition and cellular response to novel biodegradable composite wound dressings with controlled release of antibiotics

Acta Biomaterialia
Jonathan J ElsnerMeital Zilberman

Abstract

About 70% of all people with severe burns die from related infections, despite advances in treatment regimens and the best efforts of nurses and doctors. Although silver-eluting wound dressings are available for addressing this problem, there is growing evidence of the deleterious effects of such dressings in delaying the healing process owing to cellular toxicity. A new concept of antibiotic-eluting composite wound dressings is described here. These dressings are based on a polyglyconate mesh coated with a porous poly-(dl-lactic-co-glycolic acid) matrix loaded with antibiotic drugs. The effect of antibiotic release on bacterial inhibition was studied, and cell cytotoxicity was examined. The dressings resulted in a 99.99% decrease in the viable counts of Pseudomonas aeruginosa and Staphylococcus albus at very high initial inoculations of 10⁷-10⁸ CFU ml⁻¹ after only 1 day, while such a decrease in Staphylococcus aureus was obtained within 3 days. Bacterial inhibition zones around the dressing material were found to persist for 2 weeks, indicating a long-lasting antimicrobial effect. Despite severe toxicity to bacteria, the dressing material was found to have no toxic effect on cultured fibroblasts, indicating that the new antibi...Continue Reading

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Citations

Mar 26, 2011·Journal of Materials Science. Materials in Medicine·C IgnacioR L Oréfice
Mar 15, 2012·Journal of Materials Science. Materials in Medicine·Wen-Ying HuangYu-Hsin Lin
Apr 1, 2014·Cutaneous and Ocular Toxicology·Wen Zhong
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Sep 11, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Alireza Rezapour-LactoeeJafar Ai
Feb 27, 2014·ACS Applied Materials & Interfaces·Cheng-Hung LeeJyuhn-Huarng Juang
Oct 25, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Huinan ChenXiaohong Hu
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Dec 2, 2017·Macromolecular Bioscience·Lei WangXiaoyang Xu
Apr 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Salvatore FedericoGaetano Giammona

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