In vitro mitigation of arsenic toxicity by tea polyphenols in human lymphocytes

Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer
Dona SinhaMadhumita Roy

Abstract

The groundwater arsenicals have brought dreadful misery for the people residing in the endemic regions of West Bengal, India. Arsenic-related anomalies include arsenicosis, hyperkera-tosis, gastric complications, liver fibrosis, peripheral neuropathy, and cancer. Some of these diseases have been frequently associated with overproduction of reactive oxygen species that cause DNA damage and improper functioning of body's antioxidant defense mechanism. Natural polyphenols present in tea serve as excellent antioxidants. In the present study, an attempt has been made to elucidate the role of representative polyphenols and extracts of green and black tea in modulating sodium arsenite (As III)-induced DNA damage in normal human lymphocytes. Comet assay was used to detect the DNA damage. Arsenic-induced oxidative stress was measured with generation of reactive oxygen species, lipid peroxidation, and activity of some antioxidant enzymes. Expression of some repair enzymes such as poly(ADP-ribose) polymerase and DNA polymerase beta was measured to assess the effect of tea on DNA repair. Tea afforded efficient reduction of As III-induced DNA damage in human lymphocytes. Tea also quenched the excessive production of reactive oxygen species ...Continue Reading

Citations

Aug 24, 2012·Archives of Toxicology·Dona SinhaAnupam Bishayee
Jan 26, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D SinhaM Roy
Oct 20, 2009·Journal of Ethnopharmacology·Cristiano José da SilvaCatarina Satie Takahashi
Jul 9, 2014·Advances in Pharmacological Sciences·Elio A SoriaGuillermina A Bongiovanni
Oct 11, 2016·The Journal of Nutritional Biochemistry·Lixia ChenChwan-Li Shen
Jan 9, 2010·Human & Experimental Toxicology·Jaydip BiswasMadhumita Roy

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