In vitro model to assess the adsorption of oral veterinary drugs to mycotoxin binders in a feed- and aflatoxin B1-containing buffered matrix

Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
Siegrid De BaereSiska Croubels

Abstract

Mycotoxin binders are feed additives which are mixed in the feed to adsorb mycotoxins and thereby reducing their toxic effects on animals. Interactions with orally administered veterinary medicinal products, such as antimicrobials or coccidiostats, have been reported previously. This paper describes an in vitro model to screen the interaction between mycotoxin binders and veterinary drugs with respect to the non-specific binding of drugs. It is designed as a static setup using a single concentration of drug and binder in a feed-containing or a feed-plus-mycotoxin-containing matrix, buffered at different pH values. The model was applied to two frequently used antimicrobials in veterinary medicine, doxycycline (DOX) and tylosin (TYL), one major mycotoxin, aflatoxin B1 (AFB1), and four mycotoxin binders. Proportions of feed, DOX or TYL, AFB1, and binder are equivalent to the in vivo situation for broiler chickens, while pH and volume of the buffer are representative of the gastrointestinal tract of chickens. A substantial binding of DOX (~ 88%) and TYL (~ 66%) to the feed-matrix was observed. For the mycotoxin binders, similar results were obtained for DOX and TYL; more specifically up to an inclusion rate of 20 g binder/kg feed, ...Continue Reading

References

May 1, 1985·Poultry Science·G M PestiL R Minear
Aug 1, 1995·Journal of Pharmaceutical and Biomedical Analysis·J PaesenJ Hoogmartens
Apr 4, 2000·Journal of Veterinary Pharmacology and Therapeutics·K BaertP De Backer
Aug 12, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Giuseppina AvantaggiatoAngelo Visconti
Feb 13, 2007·Mycopathologia·Monica Sabater-VilarJohanna Fink-Gremmels
Jul 20, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·S De BaereS Croubels
Jul 4, 2012·The Veterinary Journal·Mathias DevreeseSiska Croubels
Oct 20, 2012·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Mathias DevreeseSiska Croubels

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Citations

Jan 23, 2021·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Ilse VanhoutteLeen De Gelder
Mar 31, 2021·Australian Veterinary Journal·P GrayUNKNOWN Australian Veterinary Association Ltd and Animal Medicines Australia

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