In vitro models for the study of osteoarthritis

The Veterinary Journal
Craig I JohnsonDylan N Clements

Abstract

Osteoarthritis (OA) is a prevalent disease of most mammalian species and is a significant cause of welfare and economic morbidity in affected individuals and populations. In vitro models of osteoarthritis are vital to advance research into the causes of the disease, and the subsequent design and testing of potential therapeutics. However, a plethora of in vitro models have been used by researchers but with no consensus on the most appropriate model. Models attempt to mimic factors and conditions which initiate OA, or dissect the pathways active in the disease. Underlying uncertainty as to the cause of OA and the different attributes of isolated cells and tissues used mean that similar models may produce differing results and can differ from the naturally occurring disease. This review article assesses a selection of the in vitro models currently used in OA research, and considers the merits of each. Particular focus is placed on the more prevalent cytokine stimulation and load-based models. A brief review of the mechanism of these models is given, with their relevance to the naturally occurring disease. Most in vitro models have used supraphysiological loads or cytokine concentrations (compared with the natural disease) in orde...Continue Reading

References

Sep 1, 1992·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J J ParkkinenM Tammi
Sep 1, 1990·Annals of the Rheumatic Diseases·C I WestacottP A Dieppe
Feb 14, 1990·Biochemical and Biophysical Research Communications·R A BunningJ Van Damme
Sep 10, 1995·Archives of Biochemistry and Biophysics·J E JeffreyR M Aspden
Mar 1, 1997·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·D A Lee, D L Bader
Jan 8, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Y KatoL F Bonewald
Oct 26, 1999·Journal of Biomechanical Engineering·P A TorzilliD L Helfet
May 12, 2000·Osteoarthritis and Cartilage·C I WestacottC J Elson
Oct 14, 2000·Archives of Biochemistry and Biophysics·A M LoeningM W Lark
Aug 24, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·C T ChenG Lust
Jan 10, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·R C MurrayA E Goodship
Feb 14, 2002·Osteoarthritis and Cartilage·D D D'LimaM K Lotz
Jan 1, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Takashi IkenoueR Lane Smith
Jan 15, 2003·Annals of the Rheumatic Diseases·T UshiyamaY Matsusue
Sep 4, 2003·The Journal of Biological Chemistry·Paul J FanningStephen B Trippel
Aug 12, 2004·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Carl-Johan SilfverswärdOsten Ljunggren
Jun 21, 2005·Osteoarthritis and Cartilage·J S HuntleyA C Hall
Sep 20, 2005·Osteoarthritis and Cartilage·C SanchezY E Henrotin
May 26, 2007·Veterinary Immunology and Immunopathology·Lindsey J MaccouxDylan N Clements
Jul 4, 2007·American Journal of Veterinary Research·Pooi-See ChanMichael W Orth
Oct 17, 2007·The Veterinary Journal·Dylan N ClementsPhilip J R Day
Feb 14, 2008·BMC Musculoskeletal Disorders·Yvonne H SniekersSimon C Mastbergen
Jul 26, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Andreas R KlattKlaus Wielckens

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Citations

Dec 10, 2015·Frontiers in Physiology·Rebecca Lewis, Richard Barrett-Jolley
Mar 13, 2018·Lubricants·Teresa VeselackMarkus A Wimmer
Dec 5, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Scott A RodeoSuzanne Maher
Apr 1, 2020·Polymers·Ian J VillamagnaElizabeth R Gillies
Mar 19, 2020·Chinese Medical Journal·Zhi-Zhong YeYue Zhang
Jul 7, 2019·Nature Biomedical Engineering·Riccardo Gottardi
Jun 28, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Meike W A KleuskensKeita Ito
Jul 30, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Csaba MattaAli Mobasheri
Nov 18, 2017·Annals of Biomedical Engineering·Michael NeidlinLeonidas G Alexopoulos
Oct 9, 2019·BMC Complementary and Alternative Medicine·Zhiguang QiaoMing Liu
Aug 4, 2019·International Journal of Molecular Sciences·Consuelo AriasLuis A Salazar
May 14, 2020·F1000Research·Michael D BriggsKatarzyna A Pirog
Mar 27, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Kil-Joon BaeSeon-Jong Kim
Feb 18, 2020·Calcified Tissue International·Hasmik Jasmine SamvelyanKatherine Ann Staines
Jun 20, 2019·Frontiers in Pharmacology·Cindy B McReynoldsBruce D Hammock
Oct 21, 2020·Annals of the Rheumatic Diseases·Jamie SoulDavid A Young
Nov 21, 2020·Membranes·Monika WasyłeczkoAndrzej Chwojnowski
Jan 7, 2021·Tissue Engineering. Part C, Methods·Meagan J MakarczykHang Lin
Feb 11, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Magdalena KusaczukMarzanna Cechowska-Pasko

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