In vitro models of human T cell anergy

Current Protocols in Immunology
Leonard J Appleman, Vassiliki A Boussiotis

Abstract

T cell anergy (acquired unresponsiveness) is an important mechanism for tolerance of self antigens. Human helper T cell clones rendered anergic in vitro are valuable tools for studying the molecular mechanisms of T cell tolerance. This unit outlines the induction and assessment of anergy in human CD4+ helper T cell clones that are reactive against MHC class II alloantigens.

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