In vitro modulation of CNS beta-receptor number by antidepressants and beta-agonists

European Journal of Pharmacology
D C U'Prichard, S J Enna

Abstract

In vitro incubation of rat cerebral cortex slices with antidepressant drugs reduced beta-adrenergic receptor binding of 3H-dihydroalprenolol by 30%. The decrease was maximum after 60 min, and was reversible after 120 min. (-)-Isoproterenol incubation caused a rapid and reversible loss (60%) of beta-receptor binding. Both effects were due to a decrease in beta-receptor sites. In vitro beta-receptor subsensitivity due to desipramine and isoproterenol was non-additive. The observed reversible loss of beta-receptor sites may be an initial phase of the beta-receptor down-regulation by antidepressants seen in vivo.

References

Jan 1, 1982·Journal of Neural Transmission·J J Scuvée-Moreau, T H Svensson
Jan 1, 1993·Psychopharmacology·R PohlR Berchou
Jan 1, 1981·Pharmacology & Therapeutics·M F Sugrue
Jan 23, 2019·Brain and Neuroscience Advances·S Clare Stanford, David J Heal
Mar 17, 2017·Neural Plasticity·Urszula DoboszewskaKatarzyna Młyniec

Citations

Feb 1, 1978·Biochemical Pharmacology·F SulserP L Mobley
Apr 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H R Wagner, J N Davis
Jun 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·D M Chuang, E Costa

Related Concepts

Brain
Receptor Down-Regulation
Adrenergic beta-Agonists
Novodrin
Beta-adrenergic receptor
Desipramine Measurement
Norepinephrine Receptors
Isoproterenol
Agonist
Thymoleptics

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