In vitro mutagenicity assessment of aluminium oxide nanomaterials using the Salmonella/microsome assay

Toxicology in Vitro : an International Journal Published in Association with BIBRA
A BalasubramanyamParamjit Grover

Abstract

The aim of the current study was to evaluate the potential mutagenicity of aluminium oxide nanomaterials (NMs) (Al(2)O(3)-30 nm and Al(2)O(3)-40 nm). Characterization of the NMs was done before the initiation of the study. The mutagenicity of the NMs was studied by the Ames test with Salmonella typhimurium TA100, TA1535, TA98, TA97a and TA102 strains, in the presence and absence of the S9 mixture. Based on a preliminary cytotoxicity study conducted on the strains, different concentrations of Al(2)O(3)-30 nm, Al(2)O(3)-40 nm and Al(2)O(3)-bulk were selected. At all the concentrations tested, Al(2)O(3)-30 nm and Al(2)O(3)-40 nm did not significantly increase the number of revertant colonies compared to the Al(2)O(3)-bulk and control with or without S9 mixture. Our findings suggest that Al(2)O(3) NMs were devoid of any size and concentration dependent mutagenicity compared to the Al(2)O(3)-bulk and control.

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Citations

Feb 27, 2013·Environmental Health and Toxicology·Ha Ryong KimKyu Hyuck Chung
Jan 1, 2011·Reviews on Environmental Health·Hong XieJohn Pierce Wise
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Aug 8, 2021·International Journal of Environmental Research and Public Health·Jing ZhangYuexiang Gao

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