In-vitro myoglobin clearance by a novel sorbent system

Artificial Cells, Blood Substitutes, and Immobilization Biotechnology
Viktoriya I KuntsevichJames F Winchester

Abstract

Rhabdomyolysis may lead to acute kidney injury following deposition of myoglobin in renal tubules. Although high-flux dialysis membranes may remove a substantial amount of myoglobin from plasma, this may still not be sufficient to prevent renal damage. We tested a new polymer sorbent, X-Sorb, in vitro to determine its potential to clear myoglobin from solutions. Normal saline or human serum in which myoglobin was dissolved was perfused by a peristaltic pump through a column packed with the sorbent. After a 4-hour perfusion, the myoglobin level in normal saline fell from 200,000 ng/ml to virtually undetectable (<780 ng/ml). Perfusion through the sorbent was then found to lower concentrations of dissolved myoglobin in 3 different 110-ml samples of human serum consistently by > 90% over 4 hours. X-Sorb appears to be an effective sorbent for myoglobin and warrants a trial in vivo to determine whether it is equally effective and safe.

References

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Citations

Dec 17, 2015·The Journal of Trauma and Acute Care Surgery·Ian J StewartKevin K Chung
Jan 31, 2015·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Marion Wiegele, Claus G Krenn
Mar 20, 2015·The Journal of Antimicrobial Chemotherapy·Michael ZollerJohannes Zander
May 20, 2017·The International Journal of Artificial Organs·Khosrow S HouschyarFrank Siemers
May 20, 2017·The International Journal of Artificial Organs·Karl TrägerHelmut Reinelt
Jan 23, 2020·Scientific Reports·Karl-Gustav RuggebergMaryann C Gruda

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