In vitro neuronal cytotoxicity of latex and nonlatex orthodontic elastics

American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics
Mark Hanson, Doug Lobner

Abstract

Although the toxicity of many dental materials has been thoroughly investigated, the toxicity of orthodontic elastic materials has not been extensively tested. We evaluated the neurotoxicity of 3 latex and 3 nonlatex orthodontic elastics in murine cerebral cortical cell cultures. Standard-sized pieces of each material from 3 manufacturers (American, Masel, and GAC) were placed on culture well inserts, allowing the material to be exposed to the culture bathing media without causing physical disruption of the cells. Cell death was quantified by assaying the release of the cytosolic enzyme lactate dehydrogenase. Exposure of cortical cultures to the nonlatex elastics did not cause significant neuronal death, but exposure to each of the latex elastics resulted in significant neuronal death. The neuronal death induced by each of the latex elastics was blocked by adding the metal chelator, EDTA (calcium disodium ethylenediaminetetraacetate). Because many latexes use zinc-containing compounds in the prevulcanization process, and the death induced had characteristics similar to zinc-induced neuronal death, it seems likely that the toxicity of latex elastics was mediated by zinc release. Because ingestion of zinc is not a health risk, th...Continue Reading

Citations

Mar 10, 2007·Journal of Orthodontics·M A HainJ E Harrison
Mar 24, 2010·Biological Trace Element Research·Marcin Mikulewicz, Katarzyna Chojnacka
Jan 18, 2011·European Journal of Orthodontics·Noelia LópezManuel Canteras
May 28, 2011·The Angle Orthodontist·Daniel J FernandesAlvaro M Mendes
Jan 24, 2019·Dental press journal of orthodontics·Daniela Ferreira de Carvalho NotarobertoCátia Cardoso Abdo Quintão
Jan 19, 2010·Orthodontics & Craniofacial Research·R L dos SantosA C de Oliveira Ruellas
Jan 5, 2011·Brazilian Dental Journal·Rogério Lacerda dos SantosAntônio Carlos de Oliveira Ruellas
Dec 14, 2011·The Angle Orthodontist·Rogério Lacerda Dos SantosMaria Teresa Villela Romanos
Jan 30, 2014·Brazilian Dental Journal·Rogério Lacerda dos SantosMaria Teresa Villela Romanos
Jun 13, 2015·The Angle Orthodontist·Sara Martínez-ColomerLea Assed Bezerra Silva
Dec 16, 2009·Journal of Orthodontics·Anjli PatelJonathan Sandler
Jul 28, 2017·Journal of Orthodontics·Ariane Salgado GonzagaSergei Godeiro Fernandes Rabelo Caldas
Oct 13, 2011·ISRN Dentistry·Daniel J FernandesAlvaro M Mendes
Aug 12, 2009·Journal of Applied Oral Science : Revista FOB·Rogério Lacerda Dos SantosAntônio Carlos De Oliveira Ruellas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Journal of Dental Research
Doug Lobner, M Asrari
Orthodontics & Craniofacial Research
Rogério Lacerda dos SantosAntônio Carlos De Oliveira Ruellas
American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics
K A RussellJ M Lee
Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics
Anne HuhtalaHannu Uusitalo
Brazilian Dental Journal
Rogério Lacerda dos SantosAntônio Carlos de Oliveira Ruellas
© 2022 Meta ULC. All rights reserved