Abstract
Angelica shikokiana is widely marketed in Japan as a dietary food supplement. With a focus on neurodegenerative conditions such as Alzheimer's disease, the aerial part was extracted and through bio-guided fractionation, fifteen compounds [α-glutinol, β-amyrin, kaempferol, luteolin, quercetin, kaempferol-3-O-glucoside, kaempferol-3-O-rutinoside, methyl chlorogenate, chlorogenic acid, hyuganin E, 5-(hydroxymethyl)-2-furaldehyde, β-sitosterol-3-O-glucoside, adenosine (isolated for the first time from A. shikokiana), isoepoxypteryxin and isopteryxin] were isolated. Isolated compounds were evaluated for in vitro neuroprotection using acetylcholine esterase inhibitory, protection against hydrogen peroxide and amyloid β peptide (Aβ25-35)-induced neurotoxicity in neuro-2A cells, scavenging of hydroxyl radicals and intracellular reactive oxygen species and thioflavin T assays. Quercetin showed the strongest AChE inhibition (IC50 value = 35.5 µM) through binding to His-440 and Tyr-70 residues at the catalytic and anionic sites of acetylcholine esterase, respectively. Chlorogenic acid, its methyl ester, quercetin and luteolin could significantly protect neuro-2A cells against H2O2-induced neurotoxicity and scavenge hydroxyl radical and in...Continue Reading
References
Aug 23, 1991·Science·J L SussmanI Silman
Jan 1, 1990·Free Radical Biology & Medicine·E R Stadtman
May 1, 1989·Journal of Ethnopharmacology·Y Kimura, H Okuda
Dec 15, 1986·Thrombosis Research·S F Mohammad, S C Woodward
Oct 1, 1994·Journal of Neurochemistry·C SotoN C Inestrosa
Feb 1, 1994·Protein Science : a Publication of the Protein Society·P H AxelsenJ L Sussman
Oct 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·M HarelJ L Sussman
Jun 1, 1997·Journal of Neurochemistry·D A ButterfieldJ M Carney
May 29, 2000·The Journal of Biological Chemistry·E HughesA J Doig
Jul 6, 2000·Progress in Neurobiology·S MirandaN C Inestrosa
Apr 3, 2001·Nature Reviews. Neuroscience·H Soreq, S Seidman
Oct 9, 2001·Mechanisms of Ageing and Development·V N Talesa
Oct 26, 2001·Free Radical Biology & Medicine·A Kontush
Feb 5, 2002·Chemical & Pharmaceutical Bulletin·Zhong YuanXian Li
Aug 29, 2002·Journal of the American Chemical Society·Yingkai ZhangJ Andrew McCammon
Jul 1, 1961·Biochemical Pharmacology·G L ELLMANR M FEATHER-STONE
Aug 12, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Marco RacchiStefano Govoni
Dec 3, 2005·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Raman ChawlaGhulam Nabi Qazi
Jan 25, 2007·Nature Reviews. Molecular Cell Biology·Christian Haass, Dennis J Selkoe
Feb 9, 2007·Planta medica·Pulok Kumar MukherjeePeter J Houghton
Nov 13, 2008·Cytotechnology·Yuping LiSanetaka Shirahata
Nov 10, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hao LiuFuyu Yang
Sep 17, 2011·Journal of Neuroscience Research·Youn Joo MoonTae Young Yune
Nov 19, 2011·Fitoterapia·Hooi Poay TanHabsah Abdul Kadir
Nov 29, 2011·BMB Reports·Mi-Jeong KimHo-Geun Yoon
Aug 1, 2012·Journal of Ethnopharmacology·Se Jin ParkJong Hoon Ryu
Aug 30, 2012·Food & Function·Scott D SmidIan F Musgrave
Oct 9, 2012·Free Radical Biology & Medicine·Maitrayee SinhaSasanka Chakrabarti
Oct 16, 2012·Bioorganic & Medicinal Chemistry·Gerda BrunhoferPia Vuorela
Dec 25, 2012·Journal of Biomedical Science·Md Golam SharoarIl-Seon Park
Jun 19, 2013·Journal of Ethnopharmacology·Amira MiraKuniyoshi Shimizu
Jul 23, 2013·Food Chemistry·Xican Li
Sep 3, 2014·Journal of Molecular Graphics & Modelling·Tran Hai-Bang, Kuniyoshi Shimizu
Citations
Oct 27, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sônia PamplonaMilton da Silva
Mar 29, 2016·Journal of Agricultural and Food Chemistry·Yang LiXinhua Ding
Jul 23, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Amal SallamKuniyoshi Shimizu
Jul 28, 2016·Chemistry & Biodiversity·Amira MiraKuniyoshi Shimizu
Jul 17, 2015·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Amira MiraKuniyoshi Shimizu
Apr 19, 2018·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Hengqiang ZhaoXiao Wang
Sep 4, 2020·Natural Product Research·Amal SallamAmal A Galala
Dec 31, 2020·International Journal of Molecular Sciences·Katarzyna SocałaPiotr Wlaź
Apr 29, 2021·British Journal of Pharmacology·Keke RenWenting Wang
Aug 6, 2021·Fitoterapia·Leilei GaoDong Liu
Aug 8, 2021·Journal of Ethnopharmacology·Wei LuoXuemei Yin
Sep 11, 2021·PloS One·Ghada Mahmoud AbdelwahabAshraf Taha Khalil