In vitro neuroprotective activities of compounds from Angelica shikokiana Makino

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Amira MiraKuniyoshi Shimizu

Abstract

Angelica shikokiana is widely marketed in Japan as a dietary food supplement. With a focus on neurodegenerative conditions such as Alzheimer's disease, the aerial part was extracted and through bio-guided fractionation, fifteen compounds [α-glutinol, β-amyrin, kaempferol, luteolin, quercetin, kaempferol-3-O-glucoside, kaempferol-3-O-rutinoside, methyl chlorogenate, chlorogenic acid, hyuganin E, 5-(hydroxymethyl)-2-furaldehyde, β-sitosterol-3-O-glucoside, adenosine (isolated for the first time from A. shikokiana), isoepoxypteryxin and isopteryxin] were isolated. Isolated compounds were evaluated for in vitro neuroprotection using acetylcholine esterase inhibitory, protection against hydrogen peroxide and amyloid β peptide (Aβ25-35)-induced neurotoxicity in neuro-2A cells, scavenging of hydroxyl radicals and intracellular reactive oxygen species and thioflavin T assays. Quercetin showed the strongest AChE inhibition (IC50 value = 35.5 µM) through binding to His-440 and Tyr-70 residues at the catalytic and anionic sites of acetylcholine esterase, respectively. Chlorogenic acid, its methyl ester, quercetin and luteolin could significantly protect neuro-2A cells against H2O2-induced neurotoxicity and scavenge hydroxyl radical and in...Continue Reading

References

Oct 1, 1994·Journal of Neurochemistry·C SotoN C Inestrosa
Oct 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·M HarelJ L Sussman
Apr 3, 2001·Nature Reviews. Neuroscience·H Soreq, S Seidman
Oct 9, 2001·Mechanisms of Ageing and Development·V N Talesa
Feb 5, 2002·Chemical & Pharmaceutical Bulletin·Zhong YuanXian Li
Aug 29, 2002·Journal of the American Chemical Society·Yingkai ZhangJ Andrew McCammon
Jul 1, 1961·Biochemical Pharmacology·G L ELLMANR M FEATHER-STONE
Aug 12, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Marco RacchiStefano Govoni
Dec 3, 2005·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Raman ChawlaGhulam Nabi Qazi
Jan 25, 2007·Nature Reviews. Molecular Cell Biology·Christian Haass, Dennis J Selkoe
Nov 10, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hao LiuFuyu Yang
Jun 19, 2013·Journal of Ethnopharmacology·Amira MiraKuniyoshi Shimizu
Sep 3, 2014·Journal of Molecular Graphics & Modelling·Tran Hai-Bang, Kuniyoshi Shimizu

❮ Previous
Next ❯

Citations

Oct 27, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sônia PamplonaMilton da Silva
Mar 29, 2016·Journal of Agricultural and Food Chemistry·Yang LiXinhua Ding
Jul 23, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Amal SallamKuniyoshi Shimizu
Jul 28, 2016·Chemistry & Biodiversity·Amira MiraKuniyoshi Shimizu
Jul 17, 2015·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Amira MiraKuniyoshi Shimizu
Apr 19, 2018·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Hengqiang ZhaoXiao Wang
Dec 31, 2020·International Journal of Molecular Sciences·Katarzyna SocałaPiotr Wlaź
Aug 6, 2021·Fitoterapia·Leilei GaoDong Liu
Aug 8, 2021·Journal of Ethnopharmacology·Wei LuoXuemei Yin

❮ Previous
Next ❯

Methods Mentioned

BETA
Assay
Fluorescence

Software Mentioned

LigPlot +
Spotfire Decision Site Client
GraphPad Prism
Molegro Virtual Docker ( MVD
SoftMax Pro
Probit Analysis SPSS
SPSS
Chemsketch

Related Concepts

Related Feeds

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.