In vitro oocyte maturation: current status

Seminars in Reproductive Medicine
Daniela NogueiraJacques Montagut

Abstract

Due to its numerous clinical applications, in vitro maturation (IVM) has emerged as a significant topic in the field of assisted reproduction. IVM of germinal vesicle breakdown/metaphase I and germinal vesicle stage oocytes collected from in vitro fertilization (IVF) superovulation cycles are commonly applied with unsatisfactory results. The biological aspect of this so-called rescue in vitro oocyte maturation greatly differs from the actual IVM practice. In the latter, immature oocytes are obtained from small antral follicles of unprimed or minimally stimulated cycles aiming to avoid ovarian hyperstimulation syndrome in high-risk patients or simply as an alternative to conventional IVF in normo-ovulatory patients. Over the past decade, cases reports regarding IVM have been sporadically reported, with ~25 peer-reviewed articles currently available. These studies present variable outcomes and deal with clinical approaches about selecting the most appropriate patient population that could benefit from IVM technology. Although some of the studies are encouraging, the vast majority includes small sample sizes, thus making the data rather inconclusive. As such there is a certain reserve in the IVF community to embark on treatment cy...Continue Reading

Citations

Jan 15, 2013·Journal of Assisted Reproduction and Genetics·Margo L HennetCatherine M H Combelles
Jun 6, 2013·Journal of Assisted Reproduction and Genetics·Duo WeiPeng Wang
Oct 3, 2013·Reproductive Biomedicine Online·Roger G Gosden
Jul 31, 2013·British Journal of Pharmacology·Shuntaro Ikeda, Masayasu Yamada
May 3, 2013·Fertility and Sterility·Evelyn E Telfer, Mary B Zelinski
Jul 29, 2015·EJC Supplements : EJC : Official Journal of EORTC, European Organization for Research and Treatment of Cancer ... [et Al.]·Leslie R SchoverCecilie E Kiserud
Nov 3, 2016·Journal of Human Reproductive Sciences·Claudia González-OrtegaAntonio Martin Gutiérrez-Gutiérrez
Jul 13, 2018·Minerva ginecologica·Raffaella FabbriRenato Seracchioli
Nov 24, 2018·Journal of Assisted Reproduction and Genetics·Yong TaoX Johné Liu
Feb 26, 2019·Acta Obstetricia Et Gynecologica Scandinavica·Evelyn E Telfer
Feb 2, 2018·Molecular Human Reproduction·M McLaughlinE E Telfer
Jan 5, 2019·Archives of Gynecology and Obstetrics·Yihua LinCaihong Ma
Jun 4, 2017·Reproductive Biology and Endocrinology : RB&E·Joanna BudnaBartosz Kempisty
May 20, 2020·Frontiers in Endocrinology·Yihua LinJinliang Zhu
Jan 30, 2021·Human Fertility : Journal of the British Fertility Society·Huiying JieDavid Yiu Leung Chan
Jul 5, 2021·Journal of Assisted Reproduction and Genetics·Michel De VosRobert B Gilchrist

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