In vitro osteogenic potential of bone debris resulting from placement of titanium screw-type implants

Clinical Oral Implants Research
Cherida R DhoreJohn A Jansen

Abstract

Histological sections of preclinical animal studies have shown that new bone formation around dental implants frequently contains debris derived from the original bone. Whether such debris by itself is osteogenic, i.e., can influence the process of new bone formation after implant placement, is still unknown. We therefore aim to investigate if such debris does have osteogenic potential. To substantiate our hypothesis, we performed an in vitro study in which titanium screws were placed into animal bone, and immediately removed. Without additional treatment these were placed into a cell culture medium provided with beta-glycerophosphate. We used Von Kossa staining and scanning electron microscopy to examine calcifications on the surface of the implants. Additionally, total DNA analysis, alkaline phosphates activity, and calcium content were assessed on the screw surface. Light and electron microscopy revealed the increasing presence of calcified matter on the implant surface. DNA amounts doubled from days 1 to 6, while alkaline phosphatase activity and calcium content showed a pronounced increase over the entire incubation time. None of these phenomena occurred on the control samples in the same medium. From these results, we pro...Continue Reading

References

Nov 22, 2001·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·T Albrektsson, C Johansson
Mar 22, 2006·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Francesca D BeamanJames K DeOrio
Apr 6, 2006·Clinical Oral Implants Research·Manal M ShalabiJohn A Jansen
May 26, 2006·Journal of Dental Research·M M ShalabiN H J Creugers
Sep 16, 2006·International Journal of Oral and Maxillofacial Surgery·J C de VicenteJ S López-Arranz
Dec 1, 2006·Kidney International. Supplement·M Ketteler, C Giachelli

❮ Previous
Next ❯

Citations

May 4, 2013·Clinical Oral Implants Research·Afsheen TabassumJohn A Jansen
Aug 14, 2009·Clinical Implant Dentistry and Related Research·Afsheen TabassumJohn A Jansen
Jan 5, 2011·Clinical Oral Implants Research·Maysa M Al-MarshoodSukumaran Anil
Jul 30, 2011·Journal of Tissue Engineering and Regenerative Medicine·Afsheen TabassumJohn A Jansen
May 13, 2011·Clinical Oral Implants Research·Dieter D BosshardtNiklaus P Lang
Dec 12, 2013·Clinical Oral Implants Research·Joke DuyckKatleen Vandamme
Oct 31, 2014·Clinical Oral Investigations·Uta SchererConstantin von See
Oct 18, 2016·International Journal of Implant Dentistry·Siddharth ShanbhagAndreas Stavropoulos
Mar 10, 2010·Journal of Dental Research·A TabassumJ A Jansen
Dec 19, 2017·Clinical Oral Investigations·Nadine MarheinekeMarcus Stoetzer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.