PMID: 9635123Jun 23, 1998Paper

In vitro osteoinduction of demineralized bone

Artificial Cells, Blood Substitutes, and Immobilization Biotechnology
P TorricelliR Giardino

Abstract

Among numerous available materials for osseous repair and reconstruction, those presenting osteoinductive characteristics and promoting bone regeneration are preferable. Fresh autologous bone is one of the most effective, but it has some disadvantages and risks. Demineralized bone matrix (DBM) is considered to be a valid alternative, because it seems to show osteogenic potential, ascribed to the presence of bone morphogenetic proteins. In addition it can be prepared without difficulty and preserved without losing osteoinductive properties. The aim of the study was to evaluate the osteoinductive ability of xenogenic DBM, by testing DBM powder obtained from rabbit long bones, in cell culture of murine fibroblasts, alone or associated with electromagnetic field (EMF), that are known to exhibit biologic effects on cells: in particular they are used in orthopedics to improve bone formation. At the end of experiment, alkaline phosphatase (ALP) activity, calcium levels and cell proliferation and morphology were evaluated. A statistically significant stimulation of ALP activity and cell proliferation and a morphological change of fibroblasts were found. The results obtained show how DBM and EMF have different effects on cells, and that...Continue Reading

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Citations

Mar 19, 2003·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·P TorricelliR Giardino
Oct 17, 2002·Foot and Ankle Clinics·V James Sammarco, Laurette Chang
May 9, 2002·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Lucilia Pereira MourièsEvelyne Lopez
Nov 1, 2003·The Spine Journal : Official Journal of the North American Spine Society·Peter G Whang, Jeffrey C Wang
Dec 13, 2012·Science China. Life Sciences·Zhiyu ZhouXuenong Zou
Mar 14, 2003·Journal of Biomedical Materials Research. Part a·Satoshi TakikawaDaisuke Togawa
Jun 22, 2006·Journal of Biomedical Materials Research. Part a·Charlotte WooMartin Lind
May 9, 2021·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Wuwei LiBo Wang

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