PMID: 22361758Mar 1, 2012Paper

In vitro pharmacodynamic properties of colistin methanesulfonate and amikacin against Pseudomonas aeruginosa

Indian Journal of Medical Microbiology
C Bozkurt-Guzel, A A Gerceker

Abstract

In vitro pharmacodynamic properties of colistin methanesulfonate and amikacin were investigated by studying time-kill kinetics and post-antibiotic effect (PAE) against strains of Pseudomonas aeruginosa isolated from patients with cystic fibrosis. Synergy was investigated at 0.5 ×, 1 × and 5 × MIC of antibiotics using time-kill curve method. PAEs were determined by the standard viable counting method where bacteria in the logarithmic phase of growth were exposed for 1 h to the antibiotics at 1 × or 20 × MIC, alone and in combinations. Synergy and additive effects were detected at 1 × MIC, at 24 h. Some of the strains produced an earlier synergistic effect at 12 h. No antagonism was observed. Colistin methanesulfonate and amikacin produced PAEs 1.16 ± 0.10 to 2.25 ± 0.16 h and 0.96 ± 0.15 to 2.69 ± 0.32 h, respectively. When the antibiotics were used in combination the PAEs were prolonged to a value of 3.88 ± 0.25 h. Consequently, the Findings of this study may play useful role in selecting the appropriate combinations when a single agent is inadequate, and may have important information for optimizing the dose intervals.

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Citations

Oct 22, 2015·Expert Review of Anti-infective Therapy·Yiying CaiAndrea L Kwa
Mar 24, 2017·The Journal of Antimicrobial Chemotherapy·Yu-Feng ZhouJian Sun
Feb 26, 2021·Pharmacological Reviews·Sue C NangJian Li

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