In Vitro Pharmacological Activities and GC-MS Analysis of Different Solvent Extracts of Lantana camara Leaves Collected from Tropical Region of Malaysia

Evidence-based Complementary and Alternative Medicine : ECAM
Mallappa Kumara SwamyMohd Sayeed Akhtar

Abstract

We investigated the effect of different solvents (ethyl acetate, methanol, acetone, and chloroform) on the extraction of phytoconstituents from Lantana camara leaves and their antioxidant and antibacterial activities. Further, GC-MS analysis was carried out to identify the bioactive chemical constituents occurring in the active extract. The results revealed the presence of various phytocompounds in the extracts. The methanol solvent recovered higher extractable compounds (14.4% of yield) and contained the highest phenolic (92.8 mg GAE/g) and flavonoid (26.5 mg RE/g) content. DPPH radical scavenging assay showed the IC50 value of 165, 200, 245, and 440 μg/mL for methanol, ethyl acetate, acetone, and chloroform extracts, respectively. The hydroxyl scavenging activity test showed the IC50 value of 110, 240, 300, and 510 μg/mL for methanol, ethyl acetate, acetone, and chloroform extracts, respectively. Gram negative bacterial pathogens (E. coli and K. pneumoniae) were more susceptible to all extracts compared to Gram positive bacteria (M. luteus, B. subtilis, and S. aureus). Methanol extract had the highest inhibition activity against all the tested microbes. Moreover, methanolic extract of L. camara contained 32 bioactive componen...Continue Reading

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Citations

Apr 5, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Greetha ArumugamUma Rani Sinniah
Jun 21, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sudipta Kumar MohantyManiyam Anuradha
Jul 30, 2016·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Kavita GhosalSwati Gupta Bhattacharya
Jan 17, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Mallappa Kumara SwamyUma Rani Sinniah
Apr 21, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Mallappa Kumara SwamyUma Rani Sinniah

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