In vitro pharmacological selectivity profile of oseltamivir prodrug (Tamiflu) and active metabolite.

European Journal of Pharmacology
Lothar LindemannManfred Brockhaus

Abstract

Neuropsychiatric adverse events have been reported in influenza patients with and without exposure to oseltamivir (Tamiflu), triggering speculation as to whether oseltamivir may be interacting with any human receptors and contributing to such neuropsychiatric events. In this study, the in vitro selectivity profile of oseltamivir prodrug and active metabolite was investigated. Both compounds lacked clinically relevant pharmacological activities on human, rodent and primate neuraminidases and on a panel of 155 other molecular targets, including those relevant for mood, cognition and behavior. Neuropsychiatric adverse events observed in influenza patients are likely a phenomenon caused by the infection rather than by oseltamivir.

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Citations

Feb 9, 2012·Basic & Clinical Pharmacology & Toxicology·Christian FreichelEric P Prinssen
May 20, 2011·Basic & Clinical Pharmacology & Toxicology·Naohisa UchimuraEric P Prinssen
Feb 7, 2015·Muscle & Nerve·Koji HayashiMasahito Yamada
Jun 27, 2014·Basic & Clinical Pharmacology & Toxicology·Katsuhiko MurakiHideki Ono
May 20, 2015·Neuroscience Letters·Hidemori UchiyamaAkihisa Toda
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May 8, 2019·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Hideki Ono
Jan 22, 2011·Psychiatry Investigation·Sungho Chung, Yoo Sook Joung
Nov 4, 2020·The Journal of Pharmacology and Experimental Therapeutics·Irina G LuzinaSimeon E Goldblum

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