PMID: 6408622Jan 1, 1983Paper

In vitro pituitary hormone releasing activity of 40 residue human pancreatic tumor growth hormone releasing factor

Peptides
A ArimuraW Vale

Abstract

The hypophysiotropic activities of a synthetic human pancreatic growth hormone releasing factor (hpGRF) with 40 residues was examined in vitro using rat pituitary halves. At concentrations from 10(-10) M to 10(-7) M the peptide stimulated GH release in a dose-dependent manner with the ED50 being 1.2 x 10(-9) M. The concentration of 10(-10) M hpGRF is comparable to the basal hypophyseal portal blood levels of other known hypothalamic hypophysiotropic hormones. However, GH release was enhanced three-fold by concentration as low as 10(-12) M, though no dose-response relationship was observed up to 10(-10) M. Thus, this peptide not only stimulates the release of GH in a dose-dependent manner, but at lower concentrations also maintains elevated GH levels. The release of ACTH, beta-endorphin, LH, and FSH was not affected by hpGRF at any of the concentrations tested. At hpGRF concentrations less than 10(-7) M, the release of TSH and PRL were unaffected. However, at 10(-6) M, TSH release was enhanced about 2.5 fold and prolactin release was elevated slightly.

References

Jan 1, 1979·The Journal of Clinical Endocrinology and Metabolism·M Saeed uz ZafarL A Frohman
Jan 1, 1981·Peptides·C M TurkelsonM Shimizu

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Citations

Oct 1, 1987·Psychiatry Research·W H BerrettiniS Simmons-Alling
Jul 1, 1983·Peptides·D M JacobowitzD L Loriaux
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·T AudhyaC S Hollander
Aug 1, 1987·Journal of Endocrinological Investigation·J A GoldmanS Reichlin
Aug 1, 1986·Clinics in Endocrinology and Metabolism·A GrossmanG M Besser
Jan 16, 1985·Biochemical and Biophysical Research Communications·G VeliçelebiM M Harpold
Jan 1, 1984·Annals of the New York Academy of Sciences·A Arimura, C M Turkelson

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