In vitro placental pressure-flow behaviour is non-linear and depends on the external pressure

European Journal of Obstetrics, Gynecology, and Reproductive Biology
P Kranenburg-LakemanI Vergroesen

Abstract

To study pressure-flow behaviour of in vitro placentas under normal simulated conditions and during raised external pressures, to simulate in vivo placental hemodynamic function, and as a model for polyhydramnios and the supine hypotension syndrome. Eleven normal term human singleton in vitro placentas were perfused under optimal physiologic conditions. Perfusion pressures varied between 5 and 90 mmHg, external pressures between 4 and 30 mmHg. Venous-external pressure (mmHg) combinations included 10-4, 10-10, 20-20, 25-25, 30-30 and 10-20. Pressure-flow curves varied markedly among the 11 placentas, but all showed a non-linear, perfusion pressure-dependent resistance. The in vitro placental resistances were significantly higher than estimated in vivo values. All placentas showed inevitable leakage at the maternal side due to damage during delivery. Increased external pressures increased the placental resistance at lower perfusion pressures. Placental damage reduces the number of perfused cotyledonic capillaries. This increases the placental resistance but preserves circulatory properties. Our findings therefore, represent in vivo placental function. They may explain why polyhydramnios often persists and that polyhydramnios and ...Continue Reading

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Citations

Jan 24, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Wilfried Gyselaers, Louis Peeters
Feb 20, 2016·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Zoya GordonAriel J Jaffa
Jul 8, 2020·Journal of Clinical Medicine·Patrick GreimelDaniel Schneditz
Nov 21, 2021·Journal of Magnetic Resonance Imaging : JMRI·Daphna Link-SouraniDafna Ben Bashat

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