In vitro positive biocompatibility evaluation of glass-glass ceramic thermoseeds for hyperthermic treatment of bone tumors

Tissue Engineering. Part a
M C SerranoM Vallet-Regí

Abstract

A new kind of magnetic thermoseed for bone tissue engineering has been synthesized. The materials used are specially designed to restore bone tissue after tumor extirpation, because they exhibit bioactive behavior and the ability to act as thermoseeds for cancer treatment using hyperthermia. The L929 cell line of mouse fibroblasts has been used in a wide biocompatibility study concerning cell proliferation and morphology studies, mitochondrial function determination, lactate dehydrogenase measurement, and flow cytometry studies, including cell cycle analysis, cell size and complexity, and intracellular reactive oxygen species content. The results presented in this work indicate that these bioactive magnetic materials are highly biocompatible and show greater cell response for thermoseeds with a higher magnetic phase content. There were no significant alterations detected in the cell cycle, and the interaction between fibroblasts and the different mixtures did not induce significant apoptosis.

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Citations

Dec 29, 2015·Journal of Biomedical Materials Research. Part a·Maziar Montazerian, Edgar Dutra Zanotto
Dec 21, 2010·Biomaterials·Murali M YallapuSubhash C Chauhan
Sep 4, 2012·Journal of Biomedical Materials Research. Part a·Hueliton W KidoAna Claudia M Renno
Oct 20, 2011·Advanced Materials·María Vallet-Regí, Eduardo Ruiz-Hernández
Oct 6, 2011·Journal of Biomedical Materials Research. Part a·María AlcaideMaría Teresa Portolés
Feb 26, 2015·Journal of Tissue Engineering and Regenerative Medicine·P R Gabbai-ArmelinA C M Renno
Nov 10, 2013·Journal of Physics. Condensed Matter : an Institute of Physics Journal·A BaezaM Vallet-Regí
Feb 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Roger BorgesJuliana Marchi

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