In-vitro postantibiotic effects of miocamycin and erythromycin on gram-positive cocci

Journal of Chemotherapy
F VarottoF Fraschini

Abstract

The capability of miocamycin to induce a postantibiotic effect (PAE) on a Group A Streptococcus beta-haemolyticus clinical isolate and on Staphylococcus aureus ATCC 29213 has been studied. Erythromycin was chosen as a reference molecule. The exposure time to antibiotics was 90 min. The removal technique of the antibiotic agents consisted of a 1:200 dilution in cultural broth. Miocamycin displayed a PAE of 2 h 30 min in relation to the minimum inhibitory concentration (MIC) of Streptococcus and a PAE of 2 h 30 min in relation to the MIC of Staphylococcus. The PAE value lasting longer than the others was of 5 h 40 min towards Streptococcus and of 4 h 18 min towards Staphylococcus at a concentration eightfold the MIC. Erythromycin showed a PAE of 1 h 36 min in relation to the MIC of Streptococcus and a PAE of 1 h 30 min in relation to the MIC of Staphylococcus. The PAE value lasting longer than the others was of 3 h 15 min against Streptococcus and of 2 h 30 min against Staphylococcus at a concentration eightfold the MIC. In some cases a PAE was observed in relation to subinhibitory concentrations (1/2 MIC). Miocamycin therefore proved to possess a more evident capability to induce a PAE against the clinical isolate of Group A Str...Continue Reading

References

Jul 1, 1988·The Journal of Antimicrobial Chemotherapy·B IsakssonL Sörén
Dec 1, 1986·The Journal of Antimicrobial Chemotherapy·S GudmundssonW A Craig
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Oct 1, 1949·Journal of Bacteriology·H Eagle, A D Musselman

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Citations

Dec 1, 1990·Journal of Chemotherapy·F ScaglioneF Fraschini
Jan 1, 1991·Acta Oto-laryngologica·F FraschiniG P Pintucci
Feb 1, 1997·Expert Opinion on Investigational Drugs·H A Kirst

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