PMID: 8582079Oct 1, 1995Paper

In vitro production of parathyroid hormone-related protein by cholesteatoma and normal skin

Clinical Otolaryngology and Allied Sciences
I M CheshireD W Proops

Abstract

Severe inflammation and infection of the middle ear occasionally results in clinical evidence of bone resorption but with the addition of the cholesteatoma epithelium it becomes inevitable. This study examined production by the cholesteatoma epithelium of a bone resorbing factor, namely parathyroid hormone-related protein (PTH-rP), which would not be expected in inflammatory states alone. PTH-rP was detected in the conditioned medium of primary and secondary cell cultures derived from 12 cholesteatoma biopsies. The levels of PTH-rP were significantly greater than in control cultures of cells derived from normal scalp tissue. Production by the cholesteatoma epithelium may explain the increased incidence of bone resorption in this disease, particularly in cases where inflammation is minimal.

References

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Citations

Oct 15, 2013·The Laryngoscope·Khac-Hung NguyenYoshiaki Doi
Dec 17, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Shumin XieWei Liu
Oct 17, 2014·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·Hiroki KoizumiMotonobu Nakamura
Oct 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Guido FranciniPierpaolo Correale
Jan 13, 1999·Clinical Otolaryngology and Allied Sciences·A R BanerjeeR J Lee

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