Abstract
The development of T cell reactivity toward schistosomula during murine Schistosoma mansoni infection has been studied using an adaptation of the in vitro lymphocyte proliferation assay in which the response is elicited by exposure to living schistosomula. The reactivity measured in this system was shown to be a T lymphocyte function and to require the presence of adherent cells. This assay may therefore provide a new method for analysis of basic interactions between host cells and schistosomula. Lymph node cell responses were observed in two phases, the first of which appeared during the second week after infection, reflecting the immunogenicity of schistosome larval forms. A later, more pronounced response appeared during the chronic stage of infection, where sensitization appeared to be stimulated primarily by ongoing exposure to adult worms, rather than eggs. Lung-stage and skin-stage larvae elicited a similar degree of thymidine uptake by cells from chronically infected mice. Intact skin-stage larvae and particulate fractions provoked greater proliferation than soluble larval constituents, indicating that the lymphocyte response is directed in large part toward determinants which remain associated with the schistosomula du...Continue Reading
References
Jul 1, 1978·The Journal of Experimental Medicine·A SherM A Vadas
Apr 1, 1979·Parasitology·M Doenhoff, E Long
Jan 1, 1977·Transactions of the Royal Society of Tropical Medicine and Hygiene·O L GoldringD J McLaren
Dec 1, 1979·The Journal of Experimental Medicine·A E ButterworthJ R David
Nov 1, 1977·The American Journal of Tropical Medicine and Hygiene·A Sher
Jan 1, 1978·The Journal of Experimental Medicine·F J Ramalho-PintoS R Smithers
Sep 1, 1978·The American Journal of Tropical Medicine and Hygiene·D A DeanW E Vannier
Aug 1, 1976·Infection and Immunity·S P Katz, D G Colley
Sep 1, 1975·Cellular Immunology·M PhillipsE H Sadun
Feb 6, 1975·Nature·A CapronH Bazin
Jun 1, 1975·Parasitology·A SherP Mackenzie
Sep 11, 1975·The Journal of Experimental Medicine·A A MahmoudR C Graham
Oct 1, 1975·The Journal of Experimental Medicine·A A MahmoudP A Peters
Dec 1, 1974·The Journal of Infectious Diseases·A SherS R Smithers
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg
Mar 1, 1972·International Journal for Parasitology·J A Clegg, S R Smithers
Dec 1, 1972·Experimental Parasitology·D G Colley
Jan 1, 1966·Transactions of the Royal Society of Tropical Medicine and Hygiene·M A StirewaltW A Fregeau
Feb 1, 1980·Cellular Immunology·N van Rooijen, R van Nieuwmegen
Sep 1, 1980·Molecular and Biochemical Parasitology·J F Dubremetz, C Dissous
Apr 1, 1980·Parasitology·S R Smithers, K Gammage
Citations
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·E J PearceA Sher
Aug 1, 1991·Parasitology·E C Ratcliffe, R A Wilson
Jan 1, 1986·Immunologic Research·S L James
Jun 23, 2009·Immunology Letters·Fernanda V DurãesCristina T Fonseca
Nov 3, 2010·Parasite Immunology·T Teixeira de MeloC T Fonseca
Feb 22, 2014·Parasite Immunology·T T de MeloC T Fonseca
Nov 15, 1981·Cellular Immunology·S L JamesA Sher
Sep 5, 2006·Experimental Parasitology·Workineh Torben, Asrat Hailu
May 1, 1986·Parasite Immunology·J E Crabtree, R A Wilson
Jul 31, 2012·Acta Tropica·Juliano Michel AraujoCristina Toscano Fonseca
Mar 1, 1982·Cellular Immunology·S L JamesA Sher
May 3, 2014·PLoS Pathogens·Xiaojun ChenChuan Su
Sep 1, 1986·Parasite Immunology·E J Pearce, S L James
Jan 1, 1990·Parasite Immunology·S L JamesE Pearce
Jun 1, 1984·Infection and Immunity·S L JamesE J Leonard