PMID: 6410679Jan 1, 1983Paper

In vitro propagation of the scrapie agent. I. Transformation of mouse glia and neuroblastoma cells after infection with the mouse-adapted scrapie strain c-506

Acta Neuropathologica
P MarkovitsR Latarjet

Abstract

Seven cell lines including glia cells from mouse brains and mouse neuroblastoma cells were infected with the mouse-adapted scrapie strain c-506. During the early in vitro passages, a stimulation of growth was already observed but cellular morphology and differentiation did not alter. Later on, after 12-16 passages, six of the seven infected lines displayed cell proliferation and morphological alterations, suggesting an in vitro morphological transformation. At this stage, differentiation was no longer observed in the scrapie-infected neuroblastoma cells and all the scrapie-infected cells formed two to four times more colonies in liquid medium than the controls, and developed large tridimensional colonies in agar. The part played by the scrapie agent in these changes is discussed.

References

Dec 1, 1978·The Journal of General Virology·T AlperM C Clarke
Apr 1, 1967·The Journal of Pathology and Bacteriology·D A Haig, I H Pattison
Feb 1, 1982·The Journal of General Virology·M T BorrásC J Gibbs
Jun 1, 1981·Infection and Immunity·D T KingsburyD C Gajdusek
Nov 1, 1980·Proceedings of the Society for Experimental Biology and Medicine·R T YanagiharaD C Gajdusek
Jul 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·S B PrusinerK C Kasper

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Citations

Jan 24, 2013·Viruses·Andrea GrassmannIna Vorberg
Oct 3, 2003·British Medical Bulletin·Jérôme SolassolSylvain Lehmann
Jun 17, 2009·FEBS Letters·Mario NuvoloneMathias Heikenwalder

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