In vitro properties of a chitosan-bonded self-hardening paste with hydroxyapatite granules

Journal of Biomedical Materials Research
M Maruyama, M Ito

Abstract

A new self-hardening paste was made by using a combination of chitosan, hydroxyapatite (HA) granules, ZnO, and CaO. The sol was made by dissolving 0.1 g of chitosan in a solution of 0.1 g malic acid and 2.0 mL physiological saline solution. Mixed with 0.03 g of CaO and 0.04 g of ZnO powders was 2.77 g (55 wt %) of HA granules which had a homogeneous pore distribution and a porosity of 35-48%. The size of the granules was set for 0.1-0.3 mm. Kneading and setting of the paste generated a little amount of heat (32.8 degrees C) as compared with the heat produced by polymethyl-methacrylate (PMMA) bone cement (114.5 degrees C). The pH value of chitosan-HA-hardened composite after setting was nearly equal to that of human plasma (pH 7.4), while that of PMMA bone cement maintained an acid pH of 4.7. Hydroxyapatite granules less than 0.1 mm, 0.1-0.3 mm, or 0.3-0.6 mm were set using chitosan sol. The size of the granules did not influence the compressive strength of the set chitosan-HA-hardened composite. The greatest compressive strength of chitosan-HA-hardened composite was obtained by using 55 wt % of HA granules. The strength of the chitosan-HA-hardened composite was comparable to that of the cancellous bone derived from tibial emine...Continue Reading

References

Mar 1, 1990·The Journal of Bone and Joint Surgery. British Volume·A UchidaK Ono
Nov 1, 1990·The Journal of Bone and Joint Surgery. British Volume·D W Murray, N Rushton
Nov 1, 1986·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·M SilverbergB J Gans
Jan 1, 1988·Annals of the New York Academy of Sciences·J R ParsonsP K Bajpai
Nov 1, 1985·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·R K Gongloff, C K Montgomery
Dec 1, 1984·Acta Orthopaedica Scandinavica·B MjöbergA Rydholm
Mar 1, 1995·Journal of Biomedical Materials Research·M MaruyamaE Kitagawa
Oct 1, 1994·Biomaterials·R A MuzzarelliG Biagini
Mar 24, 1995·Science·B R ConstantzD I Rosenthal
Oct 1, 1993·Biomaterials·R A MuzzarelliC Castaldini

❮ Previous
Next ❯

Citations

Aug 22, 2000·Journal of Biomedical Materials Research·J W CalvertL E Weiss
May 12, 2006·Journal of Materials Science. Materials in Medicine·C C RibeiroM A Barbosa
Dec 1, 2007·Journal of Materials Science. Materials in Medicine·A C Tas
Mar 30, 2004·Biomaterials·C C RibeiroM A Barbosa
May 19, 2004·Biomaterials·Seok Bong KimJung-Woog Shin
Sep 27, 2003·Dental Materials : Official Publication of the Academy of Dental Materials·Shozo TakagiFrederick C Eichmiller
Dec 3, 2002·Journal of Inorganic Biochemistry·Corrado Muzzarelli, Riccardo A A Muzzarelli
Aug 4, 2011·Tissue Engineering. Part B, Reviews·Ana Rita Costa-PintoNuno M Neves
Mar 14, 2009·Dental Materials Journal·L C Chow
Apr 19, 2012·Journal of Tissue Engineering·Roman A PerezMaria-Pau Ginebra
Oct 7, 2003·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·D P MukherjeeD Smith
Mar 26, 2010·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Kah Ling LowAldo R Boccaccini
Sep 13, 2012·Journal of Biomedical Materials Research. Part a·Kimberly T Hunter, Teng Ma
Mar 24, 2016·Journal of Prosthodontics : Official Journal of the American College of Prosthodontists·Hossein E JazayeriLobat Tayebi
Mar 12, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Carlos David Grande TovarManuel N Chaur
May 8, 2003·Journal of Biomedical Materials Research. Part a·M Sivakumar, K Panduranga Rao
Mar 18, 2006·Journal of Biomaterials Applications·Limin SunLaurence C Chow
Jun 30, 2019·International Journal of Molecular Sciences·Julián Andrés Tamayo MarínCarlos David Grande Tovar
Dec 9, 2004·Chemical Reviews·M N V Ravi KumarA J Domb
May 18, 2006·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Hirokazu UdaMasayoshi Nakasu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.