PMID: 11934011Apr 6, 2002Paper

In vitro protective effects of Terminalia arjuna bark extracts against the 4-nitroquinoline-N-oxide genotoxicity

Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer
Rossana PasquiniI S Grover

Abstract

We determined the antimutagenic potential of chloroform, acetone, methanol, methanol+HCl, diethyl ether, and ethyl acetate extracts of Terminalia arjuna bark against the model mutagen 4-nitroquinoline-N-oxide (4-NQO) using the Salmonella/microsome, comet, and micronucleus (MN) tests. Salmonella typhimurium TA100 strain and human peripheral white blood cells were coincubated with various concentrations (from 5 to 500 microg) of the six extracts and 4-NQO (from 0.05 to 2 microg). We found that the 4-NQO mutagenicity was inhibited by more than 70% in the Salmonella/microsome test at the highest nontoxic extract dose of ethyl acetate (50 microg/plate), chloroform (100 microg/plate), acetone, (100 microg/plate), and methanol (500 microg/plate). A less marked antimutagenicity activity (inhibition of about 40-45%) was observed for the acidic methanol and diethyl ether extracts. The comet assay showed that acetone extract (100 microg/mL) was more effective in reducing the DNA damage caused by 4-NQO (ca. 90%), whereas the chloroform, ethyl acetate, and diethyl ether extracts were cytotoxic. In the MN test, the decrease in 4-NQO clastogenicity was observed by testing the mutagen especially with chloroform and ethyl acetate extracts (inhi...Continue Reading

Citations

Jun 23, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Galina HovhannisyanMichael Glei
Sep 28, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P F M R PáduaH H R de Andrade
Jul 27, 2011·Environmental Toxicology and Pharmacology·Ines SkandraniLeila Chekir-Ghedira
Jul 1, 2007·HFSP Journal·Stefan Schaal
Jul 24, 2008·Nursing·Gwendolyn Edwards

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