In-vitro proteinase production by oral Candida albicans isolates from individuals with and without HIV infection and its attenuation by antimycotic agents

Journal of Medical Microbiology
T WuJ Wang

Abstract

In-vitro proteinase production by oral Candida albicans isolates from patients with and without HIV infection (18 isolates from each group) was assessed by image analysis of a plate assay, with bovine serum albumin (BSA) as a substrate. The effect of sub-minimal inhibitory concentrations (sub-MICs) of nystatin, amphotericin B, clotrimazole and miconazole on in-vitro proteinase production by these yeast isolates was also investigated. Proteinase production by C. albicans isolates from patients with HIV infection was significantly greater than production by those from individuals without infection. All 18 isolates from HIV-infected individuals produced proteinase, in comparison to 56% of isolates from uninfected individuals. Pre-exposure of C. albicans isolates (seven proteinase producers from each group) to 1/4 and 1/16 MICs of nystatin, amphotericin B, clotrimazole and miconazole resulted in decreased proteinase production in all isolates tested. However, after exposure to the four antimycotic agents, proteinase production was decreased to a significantly greater extent in isolates from uninfected individuals than in those with HIV disease. Furthermore, when the relative concentration effect of antimycotic agents on proteinase ...Continue Reading

Citations

Jul 15, 2000·Oral Microbiology and Immunology·A N EllepolaL P Samaranayake
Aug 8, 2002·Oral Diseases·L P SamaranayakeP Wanzala
Mar 13, 1999·Medical Mycology·A SzkaradkiewiczT Tułecka
Apr 9, 2001·Clinical Microbiology Reviews·Y H Samaranayake, L P Samaranayake
Oct 19, 2004·Clinical Microbiology Reviews·Louis de RepentignyPaul Jolicoeur
Jul 28, 2001·Journal of Clinical Microbiology·G LuoJ Y Yau
Sep 11, 2003·Microbiology and Molecular Biology Reviews : MMBR·Julian R NaglikBernhard Hube
Mar 10, 2016·Frontiers in Microbiology·Chaminda J SeneviratneLijian Jin
Nov 30, 2015·Archives of Oral Biology·Banu Uygun-CanBirsay Gumru
Apr 11, 2015·Journal of Prosthodontics : Official Journal of the American College of Prosthodontists·Priscila Lie ToboutiVanessa Soares Lara
May 29, 2003·FEMS Immunology and Medical Microbiology·Andreas GruberReinhard Würzner
Sep 18, 2003·FEMS Immunology and Medical Microbiology·Edja Maria Melo de Brito CostaRosangela Maria de Araújo Soares
May 11, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·A N Ellepola, L P Samaranayake
Jan 17, 2009·Brazilian Oral Research·Andréa Lusvarghi WitzelMônica Andrade Lotufo
Nov 20, 1997·The Journal of Biological Chemistry·G Newport, N Agabian
Feb 16, 2019·Journal of Prosthodontics : Official Journal of the American College of Prosthodontists·Amir Horiquini BarbosaRegina Célia Candido
Jun 13, 2003·Mycoses·N S Dar-Odeh, A A Shehabi
Mar 9, 1999·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·A N Ellepola, L P Samaranayake

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