In vitro radical scavenging and cytotoxic activities of novel hybrid selenocarbamates

Bioorganic & Medicinal Chemistry
Beatriz RomanoCarmen Sanmartín

Abstract

Novel selenocyanate and diselenide derivatives containing a carbamate moiety were synthesised and evaluated in vitro to determine their cytotoxic and radical scavenging properties. Cytotoxic activity was tested against a panel of human cell lines including CCRF-CEM (lymphoblastic leukaemia), HT-29 (colon carcinoma), HTB-54 (lung carcinoma), PC-3 (prostate carcinoma), MCF-7 (breast adenocarcinoma), 184B5 (non-malignant, mammary gland derived) and BEAS-2B (non-malignant, derived from bronchial epithelium). Most of the compounds displayed high antiproliferative activity with GI50 values below 10μM in MCF-7, CCRF-CEM and PC-3 cells. Radical scavenging properties of the new selenocompounds were confirmed testing their ability to scavenge DPPH and ABTS radicals. Based on the activity of selenium-based glutathione peroxidases (GPxs), compounds 1a, 2e and 2h were further screened for their capacity to reduce hydrogen peroxide under thiol presence. Results suggest that compound 1a mimics GPxs activity. Cytotoxic parameters, radical scavenging activity and ADME profile point to 1a as promising drug candidate.

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Citations

Jul 31, 2016·European Journal of Medicinal Chemistry·Jacob Ingemar OlsenJosé G Fernández-Bolaños
Aug 3, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nuria Díaz-ArgelichCarmen Sanmartín
Aug 9, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Verónica AlcoleaElena Lizarraga
Nov 24, 2017·Metallomics : Integrated Biometal Science·Nilda V BarbosaJoão B T Rocha
Mar 23, 2017·Antimicrobial Agents and Chemotherapy·Álvaro Martín-MontesManuel Sánchez-Moreno
Mar 15, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mónica Álvarez-PérezEnrique Domínguez-Álvarez
Jan 16, 2020·Antioxidants·Ana Carolina RuberteCarmen Sanmartín
Jul 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jerzy ZakrzewskiKatarzyna Jaszczuk
Nov 16, 2016·Future Medicinal Chemistry·Azucena MarsetJosé G Fernández-Bolaños
Mar 8, 2020·Inflammopharmacology·Sneha Hariharan, Selvakumar Dharmaraj
Oct 14, 2020·Antimicrobial Agents and Chemotherapy·Mikel Etxebeste-MitxeltorenaCarmen Sanmartín
Jun 3, 2021·Antioxidants·Gorka Calvo-MartínCarmen Sanmartín
Jul 25, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Claudio SantiLuca Sancineto

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