PMID: 2503454Jan 1, 1989Paper

In vitro reactivities of blood lymphocytes from symptomatic and asymptomatic pigeon breeders to antigen and mitogens

International Archives of Allergy and Applied Immunology
P J BouicJ R Joubert

Abstract

The proliferation of blood lymphocytes in response to pigeon gammaglobulin in the presence or absence of IL2 was measured in 9 symptomatic and 12 asymptomatic pigeon breeders and 24 controls. The symptomatic breeders exhibited spontaneous lymphocyte proliferation (p less than 0.001) when compared with controls whilst lymphocytes from asymptomatic breeders required the simultaneous addition of IL2 in order to proliferate (p less than 0.001). IL2 alone did not induce cellular proliferation. Both patient groups had abnormal T-cell functions and response to lectins and, in the symptomatic group, there existed an inverse correlation (r = -0.70, p less than 0.001) between specific antibody titres to pigeon gammaglobulin and the Con A response. We conclude that both patient groups have circulating, presensitized antigen-specific lymphocytes but these require different stimulatory signals at the cellular level.

Citations

Jul 4, 2003·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Yoshio OhtaniYasuyuki Yoshizawa
Mar 19, 2002·American Journal of Respiratory and Critical Care Medicine·Milton D RossmanDimitri Monos
Feb 5, 2013·Clinical and Translational Allergy·Ioana O Agache, Liliana Rogozea
Nov 18, 2000·Chest·Y OhtaniY Yoshizawa
Dec 30, 2014·Respiratory Investigation·Kozo SuharaNaohiko Inase
Feb 13, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D E Aguilar LeónE Martínez-Cordero

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