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In Vitro Reconstitution of the Remaining Steps in Ovothiol A Biosynthesis: C-S Lyase and Methyltransferase Reactions

Organic Letters

Aug 25, 2018

Nathchar NaowarojnaPinghua Liu

Abstract

Ovothiols are thiolhistidine derivatives. The first step of ovothiol biosynthesis is OvoA-catalyzed oxidative coupling between histidine and cysteine. In this report, the remaining steps of ovothiol A biosynthesis were reconstituted in vitro. ETA_14770 (OvoB) was reported as a PLP-depen...read more

Mentioned in this Paper

Derivatives
Histidine
Protein Methylation
Desmolases
Sulfoxides
2-thiolhistidine
Lyase
Pyridoxal Phosphate
Carbon-sulfur lyase
Methylhistidines
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In Vitro Reconstitution of the Remaining Steps in Ovothiol A Biosynthesis: C-S Lyase and Methyltransferase Reactions

Organic Letters

Aug 25, 2018

Nathchar NaowarojnaPinghua Liu

PMID: 30141637

DOI: 10.1021/acs.lett.8b02332

Abstract

Ovothiols are thiolhistidine derivatives. The first step of ovothiol biosynthesis is OvoA-catalyzed oxidative coupling between histidine and cysteine. In this report, the remaining steps of ovothiol A biosynthesis were reconstituted in vitro. ETA_14770 (OvoB) was reported as a PLP-depen...read more

Mentioned in this Paper

Derivatives
Histidine
Protein Methylation
Desmolases
Sulfoxides
2-thiolhistidine
Lyase
Pyridoxal Phosphate
Carbon-sulfur lyase
Methylhistidines

Similar Papers Found In These Feeds

Biosynthetic Transformations

Biosyntheic transformtions are multi-step, enzyme-catalyzed processes where substrates are converted into more complex products in living organisms. Simple compounds are modified, converted into other compounds, or joined together to form macromolecules. Discover the latest research on biosynthetic transformations here.

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