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In Vitro Reconstruction of Nonribosomal Peptide Biosynthesis Directly from DNA Using Cell-Free Protein Synthesis

ACS Synthetic Biology

Jan 20, 2017

Anthony Whitney GoeringNeil L. Kelleher

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Abstract

Genome sequencing has revealed that a far greater number of natural product biosynthetic pathways exist than there are known natural products. To access these molecules directly and deterministically, a new generation of heterologous expression methods is needed. Cell-free protein synth...read more

Mentioned in this Paper

Protein Biosynthesis
Natural Products
FIGF gene
Genome Sequencing
Peptide Biosynthesis, Nucleic Acid-Independent
Biosynthetic Pathways
Peptide synthase
Cell-Free System
Recombinants
Stereochemistry (Molecular Function)
22
2
111
Paper Details
References
  • References39
  • Citations4
1234

In Vitro Reconstruction of Nonribosomal Peptide Biosynthesis Directly from DNA Using Cell-Free Protein Synthesis

ACS Synthetic Biology

Jan 20, 2017

Anthony Whitney GoeringNeil L. Kelleher

PMID: 27478992

DOI: 10.1021/acssynbio.6b00160

Abstract

Genome sequencing has revealed that a far greater number of natural product biosynthetic pathways exist than there are known natural products. To access these molecules directly and deterministically, a new generation of heterologous expression methods is needed. Cell-free protein synth...read more

Mentioned in this Paper

Protein Biosynthesis
Natural Products
FIGF gene
Genome Sequencing
Peptide Biosynthesis, Nucleic Acid-Independent
22
2
111

Related Papers

Paper Details
References
  • References39
  • Citations4
1234

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