PMID: 8422544Jan 1, 1993Paper

In vitro regulation of HGF-SF expression by epithelial-mesenchymal interactions

EXS
T KamalatiL Buluwela

Abstract

Studies of parameters which affect cellular proliferation, cellular differentiation together with studies of cell-cell interactions which affect cell behavior are particularly interesting in that they can be used to identify and characterise molecules which through changes in gene expression induce/inhibit cell proliferation, differentiation and movement. Such studies are crucial not only in the context of understanding growth and development, but also in understanding the processes of wound healing and regeneration as well as tumor invasion and metastasis. Here we present a summary of some cell culture models which we have developed for the study of the above-mentioned phenomenon, together with their application to the studies of regulation of HGF-SF expression.

Related Concepts

Cell Communication
Cell Differentiation Process
Cell Division Phases
Epithelial Cells
Mesothelium
Liver
Liver Regeneration
Lateral Plate Mesoderm
Hepatocyte Growth Factor

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Generating Insulin-Secreting Cells

Reprogramming cells or using induced pluripotent stem cells to generate insulin-secreting cells has significant therapeutic implications for diabetics. Here is the latest research on generation of insulin-secreting cells.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Epigenome Editing

Epigenome editing is the directed modification of epigenetic marks on chromatin at specified loci. This tool has many applications in research as well as in the clinic. Find the latest research on epigenome editing here.