In vitro relaxant and spasmolytic effects of essential oil of Pistacia integerrima Stewart ex Brandis Galls

Journal of Ethnopharmacology
R L ShiroleM N Saraf

Abstract

Pistacia integerrima J.L. Stewart ex Brandis (Family: Anacardiaceae) galls are used in Indian ethnomedicine for its anti-asthmatic, sedative and spasmolytic properties, however, there are no scientific studies demonstrating its spasmolytic activity. The present investigation deals with the evaluation of relaxant and spasmolytic activities of the essential oil isolated from the galls of Pistacia integerrima J.L. Stewart ex Brandis (EOPI). In vitro pharmacological assays were carried out on rabbit jejunum spontaneous contractions, guinea pig ileum. The present investigation studied the relaxation of basal tone of isolated guinea pig ileum by possible involvement of NO, prostaglandins, membrane Na(+) channels, potassium channel, enteric nervous system, adrenoceptors, Ca(2+) channels. Additional studies were conducted for comparison of the relaxant effects of EOPI on CaCl2 induced contraction in calcium free tyrode solution, effect on nifedipine insensitive component of ACh-induced contraction and on the contractile machinery to intracellular [Ca(2+)] on isolated guinea pig ileum. EOPI at non-relaxing dose potentiated the isoprenaline induced relaxation of rabbit jejunum. EOPI (50 µg/mL) exhibited 28% relaxation of basal tone of 60...Continue Reading

References

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Apr 19, 2008·Journal of Ethnopharmacology·Naseem Saud AhmadAurangzeb Hasan

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Citations

Sep 29, 2018·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Abdur RaufMohamed Fawzy Ramadan
May 1, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Simona Codruta HeghesLorena Filip
May 26, 2017·Cardiovascular Toxicology·Özcan Pişkin, Hilal Ayoğlu
May 5, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ze-Jun Wang, Thomas Heinbockel
Dec 21, 2021·Frontiers in Pharmacology·Rajeev K SinglaBairong Shen

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